YEMAHARA RADICAL CHIDZIDZO

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Kazhinji muviri metabolism
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Kusvibiswa kwemhepo
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Ultraviolet radiation
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Heavy simbi kusvibiswa
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Kushatiswa kwezvipembenene
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Kushatiswa kwezvipembenene

 

 

MAHARA RADICALS & ZVIRWERE

 

Kazhinji, mahara radicals anodikanwa kumitumbi, asi yakanyanyisa yemahara radicals inogona kukonzera kusaenzana kweiyo muviri kushanda, zvobva zvaendesa kune oxidative kusagadzikana kuchichinjika muzvirwere zvakasiyana siyana (zvinyorwa zvinoratidza kuti mahara radicals ndiwo manyuko ezvirwere zvakasiyana siyana).

 

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ANTIOXIDANT

 

Miviri yedu haigone kushanda isina oxygen, uye kana huwandu hwakawanda hwemahara radicals hwakawedzera, muviri uri pasi peiyo oxidative kushushikana unozokonzeresa iyo yekugadzirisa system kutadza mukubvisa yakawandisa emahara radicals. Muzviitiko zvakakosha, muviri unoda kuzadza antioxidants in vitro kubvisa zvakanyanyisa mahara radicals.

 

KUKUDZIRIDZWA KWEMAZWIZO ANODZIDZA

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L-ERGOTHIONEINE - RUDZIDZO Rutsva RWEZVINHU ZVINOGONESESA

 

EGT iri yechisiki chiral amino-acid antioxidant biosynthesized mune mamwe mabhakitiriya uye fungi. Iyo yakakosha bioactive komputa iyo yanga ichishandiswa seyakanyanya scavenger, iyo ultraviolet ray firita, mutongi weiyo oxidation-yekudzora maitiro uye maseru bioenergetics, uye yehupenyu cytoprotector, nezvimwe.
L-Ergothioneine (EGT, ERGO, CAS: 497-30-3), inozivikanwawo se (S) -pi-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole- 4-ethanaminium yemukati munyu, yakatanga yakabviswa kubva ergot naTanret C muna 1909, ipapo yakawanikwawo muropa remhuka. Yakachena EGT yakachena kristaro, inonyungudirwa mumvura, (yakanyungudika 0.9mol / L pamhepo tembiricha). Autoxidation haigone kuitika pahupi pH kukosha kana mune yakasimba alkaline mhinduro. EGT inogona kuvapo mune maviri ma isomer mafomu - thiol fomu uye thione fomu, sezvakaratidzwa pasi apa:

 

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KUSANGANISIRA

Nebatsiro remazhinji-mabasa, EGT inomira pakati pemamwe akawanda antioxidants.

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ZVAKANAKIRA

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Iine mabhenefiti eakawanda-mabasa, EGT inomira pakati pezvimwe zvakawanda antioxidantsMakomborero (achienzaniswa ne glutathione, cysteine ​​nezvimwewo):
----EGT zviri nyore kuunganidza mumasero uye iko kusungwa kunodzikama kupfuura mamwe antioxidants.
——EGT inonyanya kushanda pakudzora kufa kwemuviri kunokonzerwa nepyrogallol.
--—EGT inonyanya kutsvaira ROS kudzivirira oxidation, nepo glutathione nevamwe vachitsvaga radicals yemahara, ndokuti, zvimwe antioxidants scavenge oxidation zvigadzirwa.(1) Oleoylethanolamide (oea) - iwo mashiripiti wand ehupenyu hwako

KUFANANA KWEMWE ANTIOXIDATION

Results: EGT ndiye ainyanya kutsvagisa rusununguko radicals kana ichienzaniswa neyekare antioxidants seGSH, uric acid uye trolox. Kunyanya, iyo yepamusoro antioxidant kugona inoratidzwa neEGT vs.poxyl radicals kwakakonzera 25% kukwira kupfuura kukosha kunowanikwa nereferensi antioxidant trolox. Iko kugona kwekutsvaira kweEGT kuenda kuhydroxyl radicals yaive 60% yakakwira, zvichienzaniswa neuric acid, inomiririra chirevo antioxidant vs. hydroxyl radicals. Chekupedzisira, EGT yakaratidza yakanyanya antioxidant chiitiko zvakare kune peroxynitrite, ine simba rekutsvaira 10% yakakwira kupfuura iyo yeuric acid.

 

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DZIMWE ZVISANGANO

 

EGT inewo maitiro ekugadzirisa intracellular simba,

inowedzera kudzivirira,

kuvandudza huwandu hwekupona kwemurume,

kuchengetedza chiropa kubva mukukuvara,

kudzivirira kuzvimba,

neurodegeneration,

kukura kwehurema uye katsi.

 

 

KUFANIRA KWEMAITIRO

G ZIGI YAKAWANIKWA ZVAKAWANDA MUZVIMBO NEZVIMHUKA

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② kuraira

5-10mg pauniti yemunhu mukuru uye zvikamu zviviri kusvika ku2 zvinoramba zvichikosha mukudya kwako kwezuva nezuva.

Kwayaka: Li Yiqun, Zhou Nianbo. Biology Mashandiro uye Kunyorera kweEGT [J]. Chikafu Injiniya, 2010 chuma9 （3） ： 26-28.

Intakes zvakanyorwa seinotevera:

Vana (makore 3-11) ≤l 0 mg / zuva
Vechidiki (makore 11-21） ≤30 mg / zuva
Vakuru (makore 21-80) ≤30 mg / zuva

Tarira: 1. Madosi evana nevakuru （3 -80 makore old

           Kushandisa vakadzi vane nhumbu kana vanoyamwisa hakukurudzirwe.

Dhata sosi: Tetrahedron paunenge uchinyorera US NDI

Dhata dzinoratidza: 10.5mg / g yeOXIS's ADI (Inogamuchirwa Yezuva Nezuva).

 

③ SYNTHESIS

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KUZIVISA & KUSHANDISA

(1) ZVIEDZO

Parizvino, pane nzira nhatu dzekugadzira EGT: kemikari synthesis, dzinongoitika bio-kuburitsa (kunyanya kubva kune howa, mhuka dzeminyama uye kubviswa kweropa), uye biosynthesis nzira.

Kufananidza kweEGT Kubvisa nzira

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(2) KUSHANDISA

- EGT ine yakafara mashandisirwo muzvizoro, chikafu chinoshanda, mishonga, mishonga, biomedicine, zvichingodaro.

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(3) ZVIMWE ZVINOGONESESWA

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References

  1. Oleoylethanolamide (oea) -iye mashiripiti wand ehupenyu hwako
  2. Anandamide vs cbd: ndeipi iri nani kune hutano hwako? Zvese zvaunoda kuti uzive nezvavo!
  3. Zvese zvaunoda kuti uzive nezve nicotinamide riboside chloride
  4. Magnesium l-threonate inowedzera: mabhenefiti, muyero, uye mhedzisiro
  5. Palmitoylethanolamide (pea): mabhenefiti, muyero, mashandisiro, kuwedzera
  6. Wepamusoro 6 hutano hunobatsira hwe resveratrol zvinowedzera
  7. Wepamusoro 5 mabhenefiti ekutora phosphatidylserine (ps)
  8. Wepamusoro 5 mabhenefiti ekutora pyrroloquinoline quinone (pqq)
  9. Iyo yakanakisa nootropic yekuwedzera yealpha gpc
  10. Yakanakisa anti-kuchembera chinowedzera chenicotinamide mononucleotide (nmn

 

Chinyorwa na: Dr. Zeng

Chirevo ne:

Dr. Zeng

Co-muvambi, yekambani manejimendi manejimendi manejimendi hutungamiriri; PhD inogamuchirwa kubva kuFudan University mune organic chemistry. Anopfuura makore mapfumbamwe ezviitiko mune organic chemistry uye dhizaini dhizaini synthesis; angangoita gumi mapepa ekutsvagisa akaburitswa mune ane simba emagazini, aine anopfuura mashanu mashanu echiChinese patent.

 

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