Mushure meku 2019-kudzidza kwakapedzisa izvo Nicotinamide Mononucleotide yakachengeteka kudyiwa nevanhu kana mashandisirwo ayo akaganhurirwa kune yakatemwa muganho, akati wandei makambani ekugadzira akapinda mumusika nezvipo zvavo. Uku kuwanda kwesarudzo kwakasiya vatengi vachivhiringidzika nezve izvo Nictonimade Mononucleotide (NMN) inowedzera zvakanakira ivo. Mune maonero edu, yakanakisa yekurwisa-kukwegura inowedzera yeNicotinamide Mononucleotide (NMN) muna 2021 ikambani yeCofttek.
Cofttek ndeye A + yakayerwa kambani yanga iri mumusika kweanenge makore gumi nemaviri uye yakagadzira yakavimbika vateveri base panguva ino. Iyo NMN poda yakapihwa nekambani iyi yakaongororwa katatu, mishonga-giredhi NMN yakatorwa kubva kumakambani mamwe chete aakapa NMN kune akasiyana akakosha emakiriniki emunhu miedzo yakaitika pamusoro pemakore. Iyo NMN upfu inopihwa neCofttek inobatsira kunyudza kwayo kupinda mumuviri, nekudaro ichiwedzera bioavailability yechigadzirwa pamwe nemabasa epanyama. Zvinotonyanya kukosha, iyi poda inouya yakawanda uye iwe unogona kuichengeta kwemwedzi mitatu. Zvese, iyi ndeimwe yezvakanakisa zviripo iye zvino mumusika ine yakakwirira mushandisi chiyero uye zvinobva kukambani iyo yakaunza yakavimbika uye inoshanda zvigadzirwa gore negore.

Nicotinamide Mononucleotide MIBVUNZO

Chii chinonzi Nicotinamide Mononucleotide (NMN)?

Nicotinamide Mononucleotide (1094-61-7) kana NMN isinotide inowanikwa neakasikwa mukati mezvakawanda zvezvikafu zvatinodya. Inowanikwa mu avocado, broccoli, kango, kabichi, edamame, uye matomatisi. Nekudaro, huwandu hweNMN hupi hunopihwa nezvikafu izvi hauna kukwana kuita mabasa emuviri uye nekudaro, vanhu vanowanzorayirwa kutora maNMN ekuwedzera. Asi, nei NMN yakakosha zvakanyanya kune muviri?

Nicotinamide Mononucleotide kana NMN inotungamira kuNicotinamide Adenine Dinucleotide kana NAD +. Mumashoko akareruka, NMN ndiyo mukomboni inoshanduka kuita NAD + kuburikidza nhevedzano yekuchinja kwemakemikari kunoitika mukati memasero. NAD +, kune rimwe divi, inoonekwa seyakakosha kumuviri sezvo ichiita mabasa akakosha akati wandei, kusanganisira kuyananisa mutinhimira wemuviri, kupaza zvinovaka muviri kuburitsa simba remagetsi, nekufambisa maitiro makuru enzymatic, mamwe acho anononoka kukwegura. Nehurombo, kunyangwe NAD + inowanikwa mukati memasero ese emuviri, kugadzirwa kwayo kunodzikira nezera. Zvinotonyanya kukosha, hapana zvekudya izvo munhu anogona kudya kuti awedzere kugadzirwa kweNAD + mukati memuviri. Izvozvi, nokudaro, kuti muviri unoda NAD + inotungamira iyo inoshanduka kuita NAD + mukati mechitokisi, nokudaro ichienzanisa kudzikira kwayo mukati memuviri. Apa ndipo panoshandiswa kushandiswa kweNMN zvinowedzera.

Chii chakanakira Nmn?

NMN yakawanikwa ichivandudza basa re insulin uye kugadzirwa, zvichikonzera mamwe mabhenefiti emagetsi pamwe nekutsungirira kweglucose. Kunyanya, NMN zvinowedzera zvinogona kubatsira kushanda kudzikisira metabolic mamiriro seshuga, mafuta chiropa chirwere, uye kufutisa.

Inogona here Nmn kudzosera kukwegura?

Iyo manejimendi yeNicotinamide Mononucleotide (NMN) yakaratidzirwa kudzikisira dysfunctions dzine chekuita nekukwegura.

Iwe unowedzera sei Nmn zvakasikwa?

NMN inogona kupihwa zvakachengeteka kumakonzo uye inowanikwa zvakasikwa mune dzinoverengeka zvekudya, zvinosanganisira broccoli, kabichi, cucumber, edamame uye avocado. Chidzidzo chitsva ichi chinoratidza kuti kana NMN yanyungudika mumvura yekunwa uye ikapihwa makonzo, inoratidzika muropa murinopfuura maminetsi matatu.

Inogona here Nmn kuwedzera hurefu?

Masayendisiti akadzidza maviri akadaro mapakati, nicotinamide riboside (NR) uye nicotinamide mononucleotide (NMN), zvakanyanya kupfuura vamwe, uye iko kutsvagisa kuri kukurudzira. Ongororo dzinoverengeka dzinoratidza kuti kuwedzera pamwe neaya anotungamira kunogona kuwedzera mazinga eNAD + uye kuwedzera hupenyu hwembiriso, honye, ​​nembeva.

Inogara kwenguva yakareba sei Nmn mune yako system?

Chidzidzo chedu chazvino chinoratidza pachena kuti NMN inokurumidza kufurwa kubva mudumbu kuenda muropa kutenderera mukati me2-3 min uye zvakare yakajekeswa kubva mukutenderera kweropa kuita matishu mukati me15 min.

Chii chinoitika kana ukarega kutora Nmn?

Zvese Resveratol neNMN zvinoshanda nekuvandudza kugona kwemasero mumuviri wako kuzvigadzirisa. Nekudaro, kana iwe ukavatora iwo kwechinguva uye wozomira hazvingakonzere iwe kuti udzokere pakarepo kudunhu rawanga uri usati wavatora nekuti shanduko idzo chaidzo kugadzirisa kwesero basa.

Nmn inoita kuti utaridzike semudiki here?

"Lab yedu yakaratidza kuti kupa NMN mbeva kwemwedzi gumi nemiviri kunoratidza kushamisa kukwegura." Sekureva kwaImai, kuturikira zvawanikwa kuvanhu zvinoratidza kuti NMN inogona kupa munhu metabolism yemakore gumi kusvika makumi maviri mudiki.

Ndeipi yakanakisa yekuwedzera kune yakachembera ganda?

Iwo gumi nemaviri akanakisa ekurwisa-kukwegura anowedzera

  • Curcumin
  • EGCG
  • Collagen
  • CoQ10
  • Nicotinamide riboside uye nicotinamide mononucleotide
  • Crocin
  • Theanine
  • Rhodiola
  • Garlic
  • Astragalus
  • Fisetin
  • Resveratrol

Ndingaite sei kuti ndishandure makwinya zvisikwa?

  • Pfeka sunscreen.
  • Deredza kunwa shuga.
  • Regedza kusvuta.
  • Shandisa coconut mafuta.
  • Tora beta carotene.
  • Inwa remoni balm shizha tii.
  • Chinja nzvimbo yekurara.
  • Geza kumeso kwako.
  • Dzivisa ultraviolet mwenje
  • Simudza yako antioxidants

Ndingashandura sei kuchembera ganda?

Kubatsira varwere vavo kudzivirira kukwegura kweganda risati rasvika, dermatologists vanopa varwere vavo matipi anotevera.

  • Dzivirira ganda rako kubva kuzuva mazuva ese.
  • Nyorera wega-musuki panzvimbo pekuti uwane tan.
  • Ukasvuta, mira.
  • Dzivisa kudzokorora chiso kumeso.
  • Idya chikafu chine hutano, chakaringana.
  • Inwa doro shoma.
  • Exercise mazuva mazhinji evhiki.
  • Chenesa ganda rako zvinyoro nyoro.
  • Shamba kumeso kwako kaviri pazuva uye mushure mekudikitira zvakanyanya.
  • Regedza kushandisa zvigadzirwa zvekuchengetedza ganda zvinoruma kana kupisa.

Chii chinokurudzirwa naSinclair?

David Sinclair Anotora:

Resveratrol - 1g / zuva nezuva - mangwanani ne yoghurt (ona kwaunotenga) Nicotinamide Mononucleotide (NMN) - 1g / zuva nezuva - mangwanani (ona kwokutenga) Metformin (mishonga yemishonga) - 1g / zuva nezuva - 0.5g mangwanani & 0.5g husiku - kunze kwemazuva ekurovedza muviri.

Nmn ine mhedzisiro here?

Kana ikatorwa nemuromo: Nicotinamide riboside iri POSSIBLY SAFE painoshandiswa kwenguva pfupi. Zvimwe zvinokanganisa nicotinamide riboside zvinowanzo nyoro. Zvimwe zvinokanganisa zvinogona kusanganisira matambudziko emudumbu senge kusvotwa uye kuzvimba kana matambudziko eganda sekurumwa uye kudikitira zvakanyanya.

Ndeipi mhedzisiro mhedzisiro yeserveratrol?

Kana ikatorwa nemuromo: Resveratrol INOFANIRA KUCHENGETEKA painoshandiswa mumari inowanikwa muzvikafu. Kana ikatorwa mumadhosi kusvika ku1500 mg zuva nezuva kusvika pamwedzi mitatu, resveratrol iri POSSIBLY SAFE. Yakakwira doses inosvika 3-2000 mg zuva nezuva yakashandiswa zvakachengeteka kwemwedzi 3000-2. Zvisinei, aya mazinga akakwirira e resveratrol anowanzo kukonzera matambudziko emudumbu.

Nicotinamide yakachengeteka kutora zuva nezuva here?

Nicotinamide riboside inogona kunge yakachengeteka iine mashoma - kana paine - mhedzisiro. Muzvidzidzo zvevanhu, kutora chiuru che1,000-2,000 mami pazuva hakuna kukuvara. Zvisinei, zvidzidzo zvevanhu zvipfupi mukureba uye zvine vashoma kwazvo vatori vechikamu. Kuti uwane yakajeka pfungwa yekuchengetedza kwayo, zvakawandisa zvidzidzo zvevanhu zvinodiwa.

Nei yakawandisa NADH yakaipa?

Iyi yakawandisa NADH inogona kupaza iyo redox chiyero pakati peNADH neNAD +, uye pakupedzisira inogona kutungamira mukushushikana kweiyo oxidative uye dzakasiyana siyana metabolic syndromes.

Ndeipi iri nani Nmn kana NR?

NR inowanzo fungidzirwa seyakatungamira kwazvo kuNAD +, asi hama yayo mamorekuru NMN, nepo isiri chinhu muBasis, iri kusimudza tsiye semwana mutsva pachivharanda.

NMN ingori yakakura kupfuura NR, zvichireva kuti kazhinji inoda kuputswa kuti ikwane muchitokisi. NR, kana ichienzaniswa nedzimwe dzinotungamira NAD + (senge nicotinic acid kana nicotinamide) inotonga zvakanyanya mukugona. Asi ipa NMN musuwo mutsva, iwo waunokwanisa kukwana mukati, uye mutambo mutsva chose.

Ndeipi yakanakisa Nmn yekuwedzera?

  • Ndeipi Nmn yekuwedzera ndiyo yakanyanya kunaka?
  • NMN Sublingual Mahwendefa.
  • NAD + Ndarama Liposomal NMN.
  • NMN Makapu.

Nmn inodzosera kukwegura here?

Nzira dzekumanikidza kuwedzera kweNAD + nhanho dzakaratidzirwa kugadzirisa basa remitochondrial mumhuka dzekare, kuchinjisa kumwe kurasikirwa kuri kuitika nezera. Iko manejimendi yeNicotinamide mononucleotide (NMN) yakaratidzirwa kudzikisira dysfunctions-inosangana-kukwegura.

Yakawanda sei NMN yaunofanira kutora?

Nepo zvidzidzo zvaratidza kuti Nicotinamide Mononucleotide kana NMN yakachengeteka kuti ishandiswe nevanhu, tsvakiridzo ichiri kuitiswa kuti uone muyero unoshanda kwazvo uye kuwanda kweiyo NMN muyero muvanhu. Nekudaro, zvidzidzo zvakaitwa kusvika parizvino zvakaratidza kuti muyero unosvika mazana mashanu emamiriyoni pazuva wakachengeteka kuvarume. Mazuva ano, Nicotinamide Mononucleotide inowanikwa nenzira dzakasiyana, kusanganisira mapiritsi nehupfu. NMN yekuwedzera vanotengesa vanoti izvo zvinonwiwa zvemumuromo zvinoshanda zvakanyanya mukusimudzira kugadzirwa kweNAD + mumuviri. Izvi zvirevo zvinoenderana nekuti Slc500a12, nicotinamide nucleotide transporter, inobatsira nekumwiswa kweNMN mumatumbu.

Nmn yakafanana neb3 here?

NMN haisi. NMN haisi fomu yevhitamini B3, uye hapana makiriniki ekuyedza kuratidza kuti inowedzera NAD muvanhu. NMN haisiriwo mhando yemamorekuru yaizombofungidzirwa sevhitamini sezvo iine phosphate, iyo inokanganisa kugona kwayo kupinda mumasero.

Ndezvipi chikafu zvine huwandu hwepamusoro hweNAD +?

Chikafu chinosimudzira NAD Matanho

Kune zvimwe zvekudya zvinogona kusimudzira mazinga eNAD mumuviri. Zvimwe zvacho zvinosanganisira:

  • Dairy Milk - tsvagiridzo yakaratidza kuti mukaka wemombe isosi yakanaka yeRiboside Nicotinamide (RN). Rita remukaka mutsva wemombe une inenge 3.9µmol yeNAD +. Saka paunenge uchinakidzwa negirazi rinozorodza remukaka, uri kunyatso kuve uri mudiki uye uine hutano!
  • Hove - heino chimwe chikonzero chekuti unakirwe nehove! mamwe marudzi ehove senge tuna, salmon uye sardines zviwanikwa zvakapfuma zveNAD + yemuviri.
  • Howa - vanhu vazhinji vanofarira howa uye ivo sechikafu chenguva dzose muchikafu chavo chenguva dzose. Asi iwe waiziva here kuti howa, kunyanya iyo crimini howa, zvakare inobatsira mukuzvisarudzira kuwedzera mazinga eNAD? Hongu, ichokwadi. Saka, nakidzwa nekudya howa uye ramba uchitaridzika uye mudiki uye uchiwedzera kuyaruka!
  • Mbiriso - yeast chinhu chinoshandiswa kugadzira chingwa nezvimwe zvinogadzirwa kubheka. Mbiriso ine Riboside Nicotinamide (RN), inova inotungamira yeNAD. Hechino chimwe chikonzero chekuti unakirwe nechikafu chako chaunofarira kana mabanzi pese paunoshanyira bhekari! Nakidzwa nechikafu chako chaunofarira uchisimudzira mazinga eNAD panguva imwe chete. Zvinotonhorera sei izvo!
  • Miriwo yakasvibirira - miriwo yakasvibirira ine mhando dzese dzeuturu mukati mawo izvo zvinobatsira munzira dzakasiyana siyana. Munguva pfupi yapfuura, zvave pachena kuti miriwo yakasvibirira zvakare yakanaka sosi yeNAD yemuviri. Mimwe yemiriwo iyi inosanganisira pizi uye asparagus.
  • Zviyo Zvese - sezvakambotaurwa, Vitamin B3 zvakare ine RN, iyo inotungamira yeNAD. Zvisinei, kana miriwo, zvinhu zvekudya kana zviyo zvikagadzirwa kana kugadzirwa, vanorasikirwa nehutano hwavo pamwe neiyo vhitamini sosi. Naizvozvo, zvinokurudzirwa kuti iwe udyewo miriwo mbishi uye utore tsanga dzese panzvimbo pechikafu chakagadzirwa.
  • Deredza Pasi Zvinwiwa Zvinwiwa Zvinodhakisa - NAD inoitisa kuti ichengetedze huwandu hwesimba remuviri. Doro rinokanganisa maitiro aya uye kudzikisira kushanda kweNAD. Naizvozvo, iwe unofanirwa kudzivirira kunwa kwakanyanyisa kwezvinwiwa zvinodhaka nekuti izvo zvakare hazvina kunaka kune hutano hwako.

Ko Nmn inokonzeresa kumhanyisa?

A 'Niacin flush' ndeimwe divi mhedzisiro yekutora yakakwira doses ye supplemental niacin (Vitamin B3). Iko kuyerera kunoitika apo niacin inokonzeresa iwo madiki macapillaries ari muganda rako kuti awedzere, izvo zvinowedzera kuyerera kweropa kumusoro kweganda. Kusiyana ne vitamini B3 (niacin) zvinowedzera, nicotinamide riboside haifanire kukonzera kumeso kumeso.

Ndekupi kwandinogona kutenga Nmn muCanada?

NMN inonzi nucleotide inotorwa kubva ku ribose uye nicotinamide. Kunge nicotinamide riboside (Niagen), NMN inotora niacin, uye inotungamira kuNAD +. NMN Canada: Nicotinamide mononucleotide haisi kuwanikwa parizvino sekuwedzera kwekudya muCanada.

Nmn yakachengeteka here?

Kwemakore, ongororo dzinoverengeka dzakaitwa kuti dziongorore kuti kushandiswa kweNMN muvanhu kwakachengeteka here kana kuti kwete. Izvi zvidzidzo, nguva nenguva, zvakaratidza kuti Nicotinamide Mononucleotide yekushandisa yakachengeteka zvachose kana muyero wayo warambidzwa. Kazhinji, varume vanokurudzirwa kunamatira kune yezuva nezuva muyero usingasviki 500 mg. Zvisinei, inofanira kuiswa pachena kuti iyo FDA haisati yatendera NMN semushonga wakachengeteka. Nekudaro, kana iwe uine chero allergiki kana zvekurapa nyaya, zvakanakira iwe bvunza nachiremba wako usati watanga chero NMN inowedzera.

Ndeipi iri nani NAD kana NMN?

NAD neNMN inozivikanwa yekurwisa-kukwegura yekuwedzera zvigadzirwa, uye nechikonzero chakanaka.

Ndingaite sei kuti ndiwedzere yangu NAD + zvakasikwa?

Zvinonzwisisika Kukurudzira NAD Matanho

  • Kutsanya
  • Nicotinamide Riboside Kudya Kwekuwedzera
  • kusimbisa muviri
  • Kuwanda Kwakajeka Kwezuva Kungasave Kwakanaka!
  • Chikafu chinosimudzira NAD Matanho

Chii chandinofanira kuunza neNMN?

Kuti uvandudze maNAD + ako, iwe unogona kutora kunonoka-kuburitsa NMN capsules ine Sirtuin Activator senge Resveratrol ine yakazara-mafuta yogati iyo inobatsira kuti bioavailability yeResveratrol.

Ndinofanira kutora TMG neNMN?

Kana iwe parizvino uri kutora NMN kana kufunga nezve kutanga, funga kuibatanidza neTMG seyakawedzera rutsigiro rwe methylation. Zvimwe zvinopa methyl zvinogona kubatsira zvinosanganisira methylated B6, B12, uye folate.

Ndeupi musiyano uripo pakati peicotinamide uye nicotinamide riboside? (3)

Niacin inzira yakasanganiswa neikotini iyo muviri unokwanisa kushandura kuita NAD. Nicotinamide ndeye amide yeNiacin iyo yakafanana zvikuru neNAD uye ine mashoma mhedzisiro. Nicotinamide riboside inogadzira nicotinamide ine hunhu hwakasiyana.

Is Nmn niacin?

Kufanana nicotinamide riboside, NMN inotora niacin, uye vanhu vane enzyme dzinogona kushandisa NMN kugadzira nicotinamide adenine dinucleotide (NADH). Mumakonzo, NMN inopinda mumasero kuburikidza nematumbu madiki mukati memaminitsi gumi achishandukira kuNAD + kuburikidza neSlc10a12 NMN mutakuri.

Nicotinamide riboside yakadzika BP here?

Nicotinamide riboside inowanzoitika ichitangira nicotinamide adenine dinucleotide (NAD +), muyananisi akajeka wezvakanaka zvinokonzerwa nekarori yekudzivirira, uye nekudaro inoverengeka caloric inorambidza mimetic komputa. Isu nguva pfupi yadarika tapedza kudzidza kwekutanga kwe nicotinamide riboside yekuwedzera mune vane hutano vane makore ari pakati nepakati uye vakuru uye takaratidza kuti vhiki nhanhatu dzekuwedzera dzakadzikira systolic blood pressure (SBP) ne6 mmHg mune vanhu vane yekutanga SBP ye8-120 mmHg (yakakwidziridzwa SBP / danho 139 hypertension) zvichienzaniswa ne placebo, uye kudzikisira kuomarara, yakasimba kuzvimiririra kufanotaura kweCVD uye kuwirirana kwehurwere nekufa.

Betaine inowanikwa kupi?

Betaine inowanikwa mune zvidiki, zvirimwa, uye mhuka uye chinhu chakakosha pazvinhu zvakawanda zvekudya, zvinosanganisira gorosi, shellfish, sipinashi, uye shuga beet. Betaine izwitterionic quaternary ammonium komputa iyo inozivikanwawo sekuti trimethylglycine, glycine betaine, lycine, uye oxyneurine.

Ndezvipi zvekudya zvinomira kuunyana?

Heano gumi ezvakanakisa anti-kuchembera chikafu chekusimbisa muviri wako kune kupenya kunobva mukati.

  • Watercress
  • Tsvuku bhero pepper
  • papaya
  • Blueberries
  • Broccoli
  • sipinachi
  • Nuts
  •  
  • Mbatatisi inotapira
  • Mbeu dzematamba

Ndingatarise sei makore gumi mudiki?

  • Shandisa iyo Hydrating Mask.
  • Sarudza Chiedza Chinopenya
  • Jekesa Bvudzi Rako Zvishoma
  • Pfeka Ponytail
  • Exfoliate (Asi Usapfuure Izvo)
  • Chena Mutsetse Wako Wemvura
  • Pedzisa Kutarisisa Kwako Ne Mineral Mist

Ndingaite sei kumisa kumeso kwangu kubva mukukwegura?

  • Dzivirira ganda rako kubva kuzuva mazuva ese
  • Nyorera wega-musuki panzvimbo pekuti uwane tan
  • Ukasvuta, mira
  • Dzivisa kudzokorora chiso kumeso
  • Idya chikafu chine hutano, chakaringana
  • Inwa doro shoma
  • Exercise mazuva mazhinji evhiki
  • Chenesa ganda rako zvinyoro nyoro

Ndezvipi zvekudya zvinokuita kuti ukure nekukurumidza?

  1. Anotapira mbatatisi yemafuta eFrance
  2. Yakatsemurwa chingwa chechichena chingwa
  3. Uchi kana muchero weshuga chena
  4. Mafuta omuorivhi kana avocado yemargarine
  5. Gara nehuku ye nyama inogadzirwa
  6. Inzwa kunze kwemukaka
  7. Funga kaviri pasoda nekofi
  8. Inwa doro zvine mwero
  9. Dzivisa kubika mukudziya kukuru
  10. Shandura micheka yemupunga
  11. Counteract fructose ine lipoic acid

Ndeipi vhitamini yakanakira kumeso kumeso?

Vitamin C inogona kubatsira kudzivirira zviratidzo zvekukwegura nekuda kwebasa rayo rakakosha mumuviri collagen synthesis. Inobatsira kuporesa ganda rakakuvara uye, mune dzimwe nguva, inoderedza kuoneka kwemakwenzi. Kudya zvakakwana vhitamini C kunogona kubatsira kugadzirisa uye kudzivirira ganda rakaoma.

Nei Tichida Nicotinamide Mononucleotide (NMN)?

Kuchembera inoenderana-nenguva uye nguva-inobatsira kudzoserwa kwemabasa emuviri wemunhu. Kunyangwe kukwegura kusingadzivisike uye kusingadzivisike, vesaenzi vakapa makore kuti vanzwisise kuti maitiro aya anogona kunonoka uye kudzorwa sei. Uku kuenderera mberi kwekutsvaga kwakatungamira mukuwanikwa kwezvinhu zvakati wandei nemakomputa ane anti-kukwegura zvivakwa zvinogona kushandurwa kuita anti-kuchembera zvinowedzera Imwe yemakomputa akadaro ane akakosha ekurwisa-kukwegura zvivakwa zvine masayendisiti anonzwa kufadzwa ndeyeNMN kana Nicotinamide Mononucleotide. Muchikamu chino, tinokurukura zvese zviripo kuziva nezveNMN pamwe neakanakisa ekurwisa-kuchembera anowedzera nicotinamide mononucleotide muna 2021.

Nicotinamide Mononucleotide (NMN) Inoshandisa

Kusvikira makore mashoma apfuura, zvese zvidzidzo zvine chekuita nekushandisa kweNMN zvakaitwa pamhuka uye nepo zvidzidzo izvi zvichiratidza mibairo inovimbisa, mhedzisiro iyi yakanga isina kukwana kumisikidza zvakanakira kushandiswa kweNMN kuvanhu. Muna 2016, ongororo yakaitiswa yekuongorora kuchengetedzwa kwekushandisa kweNMN uye kosi yayo yenguva muropa remunhu. Chidzidzo chacho chakapa mhedzisiro inovimbisa. Tumira izvo, kumwe kuongorora kwakaitwa mu2016 kuongorora mashandisiro eNMN kushandiswa mune makumi mashanu evakadzi vane chirwere cheBMI, ropa glucose, uye triglycerides yeropa. Chidzidzo chakabudirira. Nekudaro, sezvo nzvimbo yekudzidzira yaive yakatemerwa vakadzi veimwe zera, vesaenzi vakatenda kuti humwe humbowo hwaidikanwa kuti uone kana kushandiswa kweNMN kwakachengeteka kuvanhu.

Naizvozvo, munguva pfupi yapfuura, mu2019, chidzidzo chakaitwa kuClinical Trial Unit yeKeio University Chikoro cheMishonga. Musoro wenyaya yekudzidza vaive gumi varume vane makore ari pakati pe10 ne40. Varume ava vakapihwa madosi kubva ku60 mg kusvika pa100 mg. Chidzidzo ichi chakagumisa kuti NMN inoregererwa nevanhu uye yakachengeteka kuidya chero bedzi mashandisirwo ayo ari akarongedzwa zvakanaka. Ichi chidzidzo chakakosha sezvo yaive yekutanga NMN kudzidza kuitiswa pavanhu kuti vadzidze zvinoitika zveNMN pahutano hwevanhu hwese. Pakangosimbiswa kuti kushandiswa kweNMN kwakachengeteka, vagadziri vakatanga kubhomba pamusika neNMN zvinowedzera, izvo zvave kujairika mazuva ano. (500) Yoshino, J., et al. (2)….

Nicotinamide Mononucleotide (NMN) Inobatsira

Muchikamu chino, tinokurukura zvingabatsire zvakabatana neNicotinamide Mononucleotide kana NMN mabhenefiti.

N NMN Inodzora Kukwegura

Imwe yemabhenefiti akakosha eNMN ndeyekuti inoderedza kukwegura. Makore mashoma apfuura David Sinclair, anozivikanwa weAustralia Biologist uye purofesa weGenetics, akapa chiratidzo chekuti NAD + inoderedza kuchembera pamwe nekutanga kwezvirwere zvinoenderana nezera muvanhu. Nekudaro, kugadzirwa kweNAD + kunoderera nezera. Saka, sevanhu zera, kudikanwa kweiyo NAD + yekutanga inowedzera mukati memiviri yavo. Apa ndipo panopinda NMN: NMN inopinda mumaseru uye inosangana nekushanduka kwemakemikari mazhinji isati yashanduka kuita NAD + uye nekudzora maitiro ezviitiko zvezera.

② Vanhu Vanotambura nechirwere cheshuga Vanogona Kubatsirwa Kubva Mukushandisa Kwayo

Chidzidzo chakaitwa kuti chidzidze kuti NMN yekuwedzeredza muromo yakabatsira sei nezvekudya uye nezveruchiva zvinoenderana neshuga mumakonzo. Chidzidzo chacho chakaratidza kuti makonzo akapihwa nemuromo NMN kuwedzeredzwa kwakaratidza kuwedzera kwekunzwa insulin pamwe nekuwedzera kwayo kuvanda. Ichi chidzidzo chakapa chimwe chinoratidza kuti Nicotinamide Mononucleotide kana NMN yekuwedzeredza nemuromo inogona kubatsira vanhu vane chirwere cheshuga.

③ NMN Kushandiswa Kunobatanidzwazve neKuvandudzwa kweMoyo Hutano

Kumwe kuongorora kwakaitwa kuti vadzidze kuti hutano hweNMN hwakakanganisa hutano hwemwoyo mune mbeva Chidzidzo ichi chakaratidza kuti NMN haina kungodzosera chete zera-rakanangana neropa uye kukuvara kwe capillary mumakonzo asi zvakare zvakatungamira pakuyerera kweropa. Chakatonyanya kushamisa inyaya yekuti makonzo akapihwa NMN achiwedzerwa nemuromo, kuputika kwemidzi mitsva yeropa kunoonekwa. Nguva pfupi yadarika, kumwe kuongorora kwakaitwa kudzidza nezveNMN pahutano hwekunzwa makonzo uye chidzidzo ichi chakaratidzawo mhedzisiro yakafanana. Izvi zvidzidzo zvakapa humbowo hwakakwana kune vanoongorora kuti vatende kuti kunwa kweNMN zvakare kunosimudzira hutano hwemwoyo muvanhu.

Nicotinamide Mononucleotide (NMN)

④ Vanhu vane Alzheimer's Vanogona Kubatsirwa neNMN Use

Mune vanhu vanotambura nechirwere cheAlzheimer, iwo mazinga eNAD anoderera zvakanyanya. Nekudaro, apo vanhu vanotambura nechirwere cheAlzheimer vanoshandisa NMN, muviri unoita nekuwedzera huwandu hweNAD +, iyo, zvakare, inotungamira mukuwedzera kwekudzora mota, yakawedzera SIRT3 geni chiitiko, yakavandudzwa ndangariro, uye kudzikisira neuroinfigueation. Nekudaro, vanhu vanotambura neAlzheimer's vanogona kubatsirwa nekudya NMN.

N NMN Inovandudzawo Itsvo Kushanda

Oral NMN kuwedzerwa kunosanganiswa neakagadziriswa itsvo basa. Izvi zvinodaro nekuti NMN inowedzera kugadzirwa kweNAD + uye SIRT1, ese ari maviri akabatana nebasa retsvo.

Ndekupi Kwokutenga Nicotinamide Mononucleotide (NMN) Poda mu Bulk?

Kana iwe uri kutsvaga kutenga Nicotinamide Mononucleotide (NMN) poda muhuwandu, nzvimbo yakanakisa yekutenga NMN powder ndeye cofttek.com. Cofttek inyanzvi yepamusorosoro yemishonga iyo yanga ichipa zvigadzirwa zvemhando yepamusoro uye zvemhando yepamusoro kubvira 2008. Iyo kambani inozvirumbidza nechikwata chinoshamisa cheR & D nevanhu vane ruzivo vakazvipira mukugadzira zvigadzirwa zvemakwikwi. Cofttek ine vanobatirana uye inopa zvigadzirwa zvayo kumakambani emishonga muChina, Europe, India, uye North America. Iyo β-Nicotinamide Mononucleotide inopihwa neCofttek ndeyemhando yepamusoro uye yakachengeteka zvachose kudyiwa nevanhu. Zvinotonyanya kukosha, kambani inopa iyi poda muhuwandu, kureva muzvikamu zve25kgs. Nekudaro, kana iwe uri kutsvaga kutenga hupfu uhwu hwakawanda, Cofttek ndiyo kambani yaunofanira kubata - ndiyo yakanakisa Nicotinamide Mononucleotide (NMN) mupfu mupi mumusika.

Chii chinonzi Nikotinamide Mononucleotide (NMN)?

Nicotinamide Mononucleotide (1094-61-7) kana NMN inonzi nucleotide inowanikwa zvakasikwa mukati mezvakawanda zvezvikafu zvatinodya. Inowanikwa muavocado, broccoli, magaka, kabichi, edamame uye matomatisi. Nekudaro, huwandu hweNMN hunopihwa nezvikafu izvi hauna kukwana kuchengetedza mabasa akakosha emuviri uye nekudaro, vanhu vanowanzo kurairwa kutora zvinowedzera zveNMN. Asi, nei NMN yakakosha kwazvo kumuviri?
Nicotinamide Mononucleotide kana NMN inotungamira kuNicotinamide Adenine Dinucleotide kana NAD +. Mumashoko akareruka, NMN ndiyo mukomboni inoshanduka kuita NAD + kuburikidza nhevedzano yekuchinja kwemakemikari kunoitika mukati memasero. NAD +, kune rimwe divi, inoonekwa seyakakosha kumuviri sezvo ichiita mabasa akakosha akati wandei, kusanganisira kuyananisa mutinhimira wemuviri, kupaza zvinovaka muviri kuburitsa simba remagetsi, nekufambisa maitiro makuru enzymatic, mamwe acho anononoka kukwegura. Nehurombo, kunyangwe NAD + inowanikwa mukati memasero ese emuviri, kugadzirwa kwayo kunodzikira nezera. Zvinotonyanya kukosha, hapana zvekudya izvo munhu anogona kudya kuti awedzere kugadzirwa kweNAD + mukati memuviri. Izvozvi, nokudaro, kuti muviri unoda NAD + inotungamira iyo inoshanduka kuita NAD + mukati mechitokisi, nokudaro ichienzanisa kudzikira kwayo mukati memuviri. Apa ndipo panoshandiswa kushandiswa kweNMN zvinowedzera. 


Nei Tichida Nicotinamide Mononucleotide (NMN)

Kuchembera kunoenderana nenguva uye nenguva-yakadzoserwa kudzoreredza kwemabasa emuviri wemunhu. Kunyangwe kuchembera kusingadzivisiki uye zvisingadzivisiki, masayendisiti akapedza makore kuti anzwisise kuti kuita uku kunogona kunonoka uye kudzorwa sei. Uku kuenderera mberi kwekutsvaga kwakonzera kuwanikwa kwezvinhu zvakati wandei uye zvakapindirana nezvinhu zvinopesana nekukwegura izvo zvinokwanisa kushandurwa kuita zvinopesana nekukwegura. Imwe yakadai svutugadzike inokosha yekudzivirira kukwegura iyo ine masayenzi inonzwa ichinakidzwa ndeye NMN kana Nicotinamide Mononucleotide. Munyaya ino, tinokurukura zvese zviripo kuti tizive nezveNMN pamwe neakanakisa ekudzivirira kukwegura anowedzera nicotinamide mononucleotide muna 2021.

Nicotinamide Mononucleotide (NMN)
Nicotinamide Mononucleotide (NMN)

Nicotinamide Mononucleotide (NMN) Inoshandisa

Kusvikira makore mashoma apfuura, zvese zvidzidzo zvine chekuita nekushandisa kweNMN zvaiitwa pamhuka uye nepo zvidzidzo izvi zvichiratidza mibairo inovimbisa, mhedzisiro iyi yakanga isina kukwana kumisikidza zvakanakira Kushandiswa kweNMN muvanhu. Muna 2016, ongororo yakaitwa yekuongorora kuchengetedzwa kwekushandiswa kweNMN uye nguva yayo muropa revanhu. Chidzidzo chacho chakaunza mhinduro dzinovimbisa. Tumira iyo, kumwe kuongorora kwakaitwa muna 2016 kudzidza nezvekushomeka kweNMN kunwa mumakumi mashanu vakadzi vane chirwere chepamusoro cheBMI, ropa glucose, uye ropa triglycerides. Chidzidzo ichi chakabudirira. Nekudaro, sezvo nzvimbo yekufunda yaingobvumidzwa kuvakadzi veimwe zera, masayendisiti akatenda kuti humwe humbowo hwaidikanwa kuratidza kana kushandiswa kweNMN kwakachengeteka kuvanhu.

Naizvozvo, munguva pfupi yapfuura, mu2019, chidzidzo chakaitwa kuClinical Trial Unit yeKeio University Chikoro cheMishonga. Musoro wenyaya yekudzidza vaive gumi varume vane makore ari pakati pe10 ne40. Varume ava vakapihwa madosi kubva ku60 mg kusvika pa100 mg. Chidzidzo ichi chakagumisa kuti NMN inoregererwa nevanhu uye yakachengeteka kuidya chero bedzi mashandisirwo ayo ari akarongedzwa zvakanaka. Ichi chidzidzo chakakosha sezvo yaive yekutanga NMN kudzidza kuitiswa pavanhu kuti vadzidze zvinoitika zveNMN pahutano hwevanhu hwese. Pakangosimbiswa izvo NMN kushandiswa kwakachengeteka, vagadziri vakatanga kubhomba pamusika neNMN zvinowedzera, izvo zvave kujairika mazuva ano.(2) Yoshino, J., et al. (2011)….

Nicotinamide Mononucleotide (NMN) Inobatsira

Muchikamu chino, tinokurukura izvo zvakanaka zvinowanikwa zvakabatana neNicotinamide Mononucleotide kana NMN mabhenefiti.

Nicotinamide Mononucleotide (NMN)

N NMN Inodzora Kukwegura

Imwe yemabhenefiti akakosha eNMN ndeyekuti inoderedza kukwegura. Makore mashoma apfuura David Sinclair, anozivikanwa weAustralia Biologist uye purofesa weGenetics, akapa chiratidzo chekuti NAD + inoderedza kuchembera pamwe nekutanga kwezvirwere zvinoenderana nezera muvanhu. Nekudaro, kugadzirwa kweNAD + kunoderera nezera. Saka, sevanhu zera, kudikanwa kweiyo NAD + yekutanga inowedzera mukati memiviri yavo. Apa ndipo panopinda NMN: NMN inopinda mumaseru uye inosangana nekushanduka kwemakemikari mazhinji isati yashanduka kuita NAD + uye nekudzora maitiro ezviitiko zvezera.

Vanhu Vanotambura nechirwere cheshuga Vanogona Kubatsirwa Kubva Pazvinoshandiswa

Chidzidzo chakaitwa kuti chidzidze kuti NMN yekuwedzeredza muromo yakabatsira sei nezvekudya uye nezveruchiva zvinoenderana neshuga mumakonzo. Chidzidzo chacho chakaratidza kuti makonzo akapihwa nemuromo NMN kuwedzeredzwa kwakaratidza kuwedzera kwekunzwa insulin pamwe nekuwedzera kwayo kuvanda. Ichi chidzidzo chakapa chimwe chinoratidza kuti Nicotinamide Mononucleotide kana NMN yekuwedzeredza nemuromo inogona kubatsira vanhu vane chirwere cheshuga.

③ NMN Kushandiswa Kunobatanidzwazve neKuvandudzwa kweMoyo Hutano

Kumwe kuongorora kwakaitwa kuti vadzidze kuti hutano hweNMN hwakakanganisa hutano hwemwoyo mune mbeva Chidzidzo ichi chakaratidza kuti NMN haina kungodzosera chete zera-rakanangana neropa uye kukuvara kwe capillary mumakonzo asi zvakare zvakatungamira pakuyerera kweropa. Chakatonyanya kushamisa inyaya yekuti makonzo akapihwa NMN achiwedzerwa nemuromo, kuputika kwemidzi mitsva yeropa kunoonekwa. Nguva pfupi yadarika, kumwe kuongorora kwakaitwa kudzidza nezveNMN pahutano hwekunzwa makonzo uye chidzidzo ichi chakaratidzawo mhedzisiro yakafanana. Izvi zvidzidzo zvakapa humbowo hwakakwana kune vanoongorora kuti vatende kuti kunwa kweNMN zvakare kunosimudzira hutano hwemwoyo muvanhu.

Nicotinamide Mononucleotide (NMN)

④ Vanhu vane Alzheimer's Vanogona Kubatsirwa neNMN Use

Mune vanhu vanotambura nechirwere cheAlzheimer, iwo mazinga eNAD anoderera zvakanyanya. Nekudaro, apo vanhu vanotambura nechirwere cheAlzheimer vanoshandisa NMN, muviri unoita nekuwedzera huwandu hweNAD +, iyo, zvakare, inotungamira mukuwedzera kwekudzora mota, yakawedzera SIRT3 geni chiitiko, yakavandudzwa ndangariro, uye kudzikisira neuroinfigueation. Nekudaro, vanhu vanotambura neAlzheimer's vanogona kubatsirwa nekudya NMN.

N NMN Inovandudzawo Itsvo Kushanda

Oral NMN kuwedzerwa kunosanganiswa neakagadziriswa itsvo basa. Izvi zvinodaro nekuti NMN inowedzera kugadzirwa kweNAD + uye SIRT1, ese ari maviri akabatana nebasa retsvo.

Nicotinamide Mononucleotide (NMN) Dosage

Nepo zvidzidzo zvakaratidza kuti Nicotinamide Mononucleotide kana NMN yakachengeteka kuti ishandiswe nevanhu, kutsvagisa kuchiri kuitwa kuti vaone iyo inonyanya kushanda dosage uye frequency ye NMN muyero muvanhu. Nekudaro, zvidzidzo zvakaitwa kusvika pari zvino zvakaratidza kuti dosage inosvika 500 mg pazuva yakachengeteka kune varume. Mazuva ano, Nicotinamide Mononucleotide inowanikwa mune dzakasiyana siyana, kusanganisira mapiritsi uye hupfu. NMN vanowedzera vatengesi vanoti zvemuromo zvinowedzera zvinoshanda pakukwiridzira NAD + kugadzirwa mumuviri. Izvi zvirevo zvinovakirwa pashoko rekuti Slc12a8, nicotinamide nucleotide transporter, inobatsira nekunzwa kweNMN mumarara.

Is Nicotinamide Mononucleotide (NMN) Yakachengeteka?

Kwemakore, ongororo dzinoverengeka dzakaitwa kuti dziongorore kuti kushandiswa kweNMN muvanhu kwakachengeteka here kana kuti kwete. Izvi zvidzidzo, nguva nenguva, zvakaratidza kuti Nicotinamide Mononucleotide yekushandisa yakachengeteka zvachose kana muyero wayo warambidzwa. Kazhinji, varume vanokurudzirwa kunamatira kune yezuva nezuva muyero usingasviki 500 mg. Zvisinei, inofanira kuiswa pachena kuti iyo FDA haisati yatendera NMN semushonga wakachengeteka. Nekudaro, kana iwe uine chero allergiki kana zvekurapa nyaya, zvakanakira iwe bvunza nachiremba wako usati watanga chero NMN inowedzera.

Ndekupi Kutenga Nicotinamide Mononucleotide (NMN) Powder muhuwandu?

Kana uri kutarisa tenga Nicotinamide Mononucleotide (NMN) poda yakawanda, nzvimbo yakanakisa yeku tenga NMN upfu is cofttek.com. Cofttek inyanzvi yepamusorosoro yemishonga iyo yanga ichipa zvigadzirwa zvemhando yepamusoro uye zvemhando yepamusoro kubva muna2008. Iyo kambani inozvirumbidza nechikwata chinoshamisa cheR & D nevanhu vane ruzivo vakazvipira mukugadzira zvigadzirwa zvemakwikwi. Cofttek ine vanobatirana uye inopa zvigadzirwa zvayo kumakambani emishonga muChina, Europe, India, uye North America. Iyo β-Nicotinamide Mononucleotide inopihwa neCofttek ndeyemhando yepamusoro uye yakachengeteka zvachose kudyiwa nevanhu. Zvinotonyanya kukosha, kambani inopa iyi hupfu muhuwandu, kureva muzvikamu zve25kgs. Nekudaro, kana iwe uri kutsvaga kutenga iyi poda muhuwandu, Cofttek ndiyo kambani yaunofanirwa kubata - ndiyo yakanyanya kunaka Nicotinamide Mononucleotide (NMN) mutengesi wepoda mumusika.

Chinyorwa na: Dr. Zeng

Chirevo ne:

Dr. Zeng

Co-muvambi, yekambani manejimendi manejimendi manejimendi hutungamiriri; PhD inogamuchirwa kubva kuFudan University mune organic chemistry. Anopfuura makore mapfumbamwe ezviitiko mune organic chemistry uye dhizaini dhizaini synthesis; angangoita gumi mapepa ekutsvagisa akaburitswa mune ane simba emagazini, aine anopfuura mashanu mashanu echiChinese patent.

References

(1). Yao, Z., et al. (2017). Nicotinamide Mononucleotide Inhibits JNK activation Kuti Idzore Alzheimer Chirwere.

(2). Yoshino, J., et al. (2011). Nicotinamide Mononucleotide, yakakosha NAD (+) Pakati, Inobata iyo Pathophysiology yeDhi uye Zera-Inokonzera Chirwere cheshuga muMakonzo. Cell Metabolism.

(3). Yamamoto, T., et al. (2014). Nicotinamide Mononucleotide, Intermediate yeNAD + Synthesis, Inodzivirira Mwoyo kubva kuIschemia uye Reperfusion.

(4). Wang, Y., et al. (2018). NAD + Supplementation Normalizes Key Alzheimer's Zvimiro uye Dhivhidhe Dzinopindura Mhinduro mune Nyowani AD Mouse Model neYakatanga Kugadziriswa kweDNA Kuwanikwa.

(5). Keisuke, O., et al. (2019). Zvinokonzerwa neakachinja NAD Metabolism muMetabolic Disorders. Zvinyorwa zveByomedical Sayenzi.

(6). Rwendo rwekuongorora egt.

(7). Oleoylethanolamide (oea) -iye mashiripiti wand ehupenyu hwako.

(8). Anandamide vs cbd: ndeipi iri nani kune hutano hwako? Zvese zvaunoda kuti uzive nezvavo!

(9). Zvese zvaunoda kuti uzive nezve nicotinamide riboside chloride.

(10). Magnesium l-threonate inowedzera: mabhenefiti, muyero, uye mhedzisiro.

(11). Palmitoylethanolamide (pea): mabhenefiti, muyero, mashandisiro, kuwedzera.

(12). Wepamusoro 6 hutano hunobatsira hwe resveratrol zvinowedzera.

(13). Wepamusoro mashanu mabhenefiti ekutora phosphatidylserine (ps).

(14). Wepamusoro mashanu mabhenefiti ekutora pyrroloquinoline quinone (pqq).

(15). Iyo yakanakisa nootropic yekuwedzera yealpha gpc.