Oleoylethanolamide (OEA) (111-58-0) Vagadziri - Cofttek

Oleoylethanolamide (OEA) (111-58-0)

April 7, 2020

Oleoylethanolamine (OEA) ndeyezvisikwa kuitika ethanolamide lipid uye nyukiliya receptor peroxisome proliferator-activated receptor-α (PPAR-α) agonist. Iyo inogadzirwa mudumbu diki uye inhibitisa chikafu chekudya kuburikidza nePPAR-α activation.


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

Oleoylethanolamide (OEA) (111-58-0) vhidhiyo

Oleoylethanolamide (OEA) Specifications

Name: Oleoylethanolamide (OEA)
CAS: 111-58-0
Purity 98%
Molecular Formula: C20H39NO2
Molecular Weight: 325.53 g / mol
Melt Point: 59-60 ° C
Kemikari zita: N-Oleoylethanolamide
Synonyms: N-Oleoylethanolamine, N- (Hydroxyethyl) oleamide, N- (chis-9-Octadecenoyl) ethanolamine, OEA
InChI Key: SUHOQUVVLLYYQR-MRVPVSSYSA-N
Hafu Hupenyu: N / A
Solubility: Soluble muDMSO, Methanol, Mvura
Chengetedzo Chimiro: 0 - 4 C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 C kwenguva refu (mwedzi)
Application: Oleoylethanolamide (OEA) ndeyemusikirwo metabolite iyo inogadzirwa mune mashoma mudumbu rako diki. OEA inobatsira kudzora nzara, uremu, mafuta emuviri uye cholesterol nekusunga kune receptor inozivikanwa sePPAR-Alpha (Peroxisome proliferator-activated receptor alpha).
Kuonekwa: White powder

Chii chinonzi Oleoylethanolamide (OEA) CAS 111-58-0?

Oleoylethanolamine (OEA) ndeyezvisikwa kuitika ethanolamide lipid uye nyukiliya receptor peroxisome proliferator-activated receptor-α (PPAR-α) agonist. Iyo inogadzirwa mudumbu diki uye inhibitisa chikafu chekudya kuburikidza nePPAR-α activation. OEA inoshandisawo GPR119, bioactive lipid ine hypophagic uye anti-kufutisa mhedzisiro.

Oleoylethanolamide (OEA) CAS 111-58-0 zvakanaka

Oleoylethanolamide (OEA) ndeyemusikirwo metabolite iyo inogadzirwa mune mashoma mudumbu rako diki. OEA inobatsira kudzora nzara, uremu, mafuta emuviri uye cholesterol nekusunga kune receptor inozivikanwa sePPAR-Alpha (Peroxisome proliferator-activated receptor alpha). Mukukosha, OEA inowedzera metabolism yemafuta emuviri uye inotaurira uropi hwako kuti iwe uzere uye inguva yekumira kudya. OEA inozivikanwa zvakare kuwedzera isina-kurovedza zvinoenderana ne calorie mari.

Oleoylethanolamide (OEA) CAS 111-58-0 Mechanism Yekuita?

Oleoylethanolamide (OEA) yakagadzirwa uye inosimudzirwa mudikitivhiti diki mudumbu kubva pakudya-kubva kune oleic acid, senge maorivhi omuorivhi. Kudya kwakawanda-kwemafuta kunogona kukanganisa eEEA kugadzirwa mudumbu. OEA inogadzirisa kudya kwekudya nekumisa homeostatic oxytocin uye histamine brain circry pamwe neyedonic dopamine nzira. Pane humbowo hwekuti OEA inogona zvakare kuwana hedonic cannabinoid receptor 1 (CB1R) chiratidzo, iyo activation yayo inoenderana nekuwedzera kwekudya. OEA inogadzirisa lipid kutakura kuenda mune adipocytes kuderedza mafuta masisi. Kupfuurirazve elucidation yemhedzisiro yeOEA pane kudya kwekudya uye lipid metabolism ichabatsira mukutsanangurwa kwemaitiro epanyama ayo anogona kutungamirwa kuti akwanise kuwedzera kurapwa kwekufutisa.

Oleoylethanolamide (OEA) ndeye agonist ye peroxisome proliferator-activated receptor-α (PPAR- α). N- Oleoylethanolamide inogadzira chiratidzo chematumbu chinosimudzira yepakati dopamine chiitiko kusimudza kubatana pakati pe caloric- homeostatic uye hedonic- homeostatic controllers. Oleoylethanolamide yakave nekukosheswa seyakakura masystem inoenderana ne gastric bypass kubudirira. N- Oleoylethanolamide inosarudza GPR55 agonist.

Oleoylethanolamide (OEA) CAS 111-58-0 kunyoresa

Oleoylethanolamide (OEA) inoshanda kuti ishandise chimwe chinhu chinodaidzwa kuti PPAR uye panguva imwe chete inokwirisa mafuta-kupisa uye kuderedza mafuta kuchengetedza. Kana iwe uchidya, OEA mazinga anowedzera uye yako yekudya inoderera kana iyo sensory nerves inosangana kune uropi hwako itaurira kuti iwe uzere. PPAR-α iboka re ligand-activated nyukiliya receptor iyo inobatanidzwa mukutaura kwe gene ye lipid metabolism uye simbahomeostasis nzira.

Oleoylethanolamide (OEA) powder Sale(Iko Kutenga Oleoylethanolamide (OEA) poda muhuwandu)

Kambani yedu inonakidzwa nehurefu hwehukama nevatengi vedu nekuti tinotarisa pakubata kwevatengi nekupa zvigadzirwa zvikuru. Kana iwe unofarira chigadzirwa chedu, isu tinoshanduka pamwe neyakagadziriswa yemirairo kuti ikwane yako chaiyo yekuda uye yedu yekukurumidza kutungamira nguva pamirairo inovimbisa kuti uchave nekuravira kwedu kukuru chigadzirwa pane-nguva. Isu tinotarisawo pamabasa akawedzerwa-kukosha. Isu tinowanikwa yemibvunzo yebasa uye ruzivo rwekutsigira rako bhizinesi.

Isu tiri nyanzvi Oleoylethanolamide (OEA) mutengesi poda kwemakore akati wandei, isu tinopa zvigadzirwa nemakwikwi emutengo, uye chigadzirwa chedu chemhando yepamusoro uye chinoedzwa chakasimba, chakazvimirira bvunzo kuyedza kuti ive yakachengeteka kuti ishandiswe pasi rese.

References

  1. Gaetani S, Oveisi F, Piomelli D (2003). "Modction yeupfu hwekudya mune iyo rat neye anoretic lipid muenzanisi oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  2. Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Mirairo yezvikafu zvinowanikwa ne oleoylethanolamine". Sero. Mol. Hupenyu Sci. 62 (6): 708–16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  3. Gaetani S, Kaye WH, Cuomo V, Piomelli D (Gunyana 2008). "Basa re endocannabinoids nemafananidziro avo mukufutisa uye matambudziko ekudya". Kudya Kurema Kurema. 13 (3): e42-8. PMID 19011363.