Oleoylethanolamide (OEA) upfu (111-58-0)

April 7, 2020

Oleoylethanolamine (OEA) ndeyezvisikwa kuitika ethanolamide lipid uye nyukiliya receptor peroxisome proliferator-activated receptor-α (PPAR-α) agonist. Iyo inogadzirwa mudumbu diki uye inhibitisa chikafu chekudya kuburikidza nePPAR-α activation.

 


Mamiriro: MuMitambo Yokugadzira
Unit: 1kg / bhegi, 25kg / Drum

OEA upfu (111-58-0) vhidhiyo

 

OEA upfu Specifications

Name: Oleoylethanolamide (OEA)
CAS: 111-58-0
Purity 98%
Molecular Formula: C20H39NO2
Molecular Kurema: 325.53 g / mol
Melt Point: 59-60 ° C
Kemikari zita: N-Oleoylethanolamide
Synonyms: N-Oleoylethanolamine, N- (Hydroxyethyl) oleamide, N- (chis-9-Octadecenoyl) ethanolamine, OEA
InChI Key: SUHOQUVVLLYYQR-MRVPVSSYSA-N
Hafu Hupenyu: N / A
Solubility: Soluble muDMSO, Methanol, Mvura
Chengetedzo Chimiro: 0 - 4 C kwenguva pfupi (mazuva kusvika kumavhiki), kana -20 C kwenguva refu (mwedzi)
Application: Oleoylethanolamide (OEA) ndeyemusikirwo metabolite iyo inogadzirwa mune mashoma mudumbu rako diki. OEA inobatsira kudzora nzara, uremu, mafuta emuviri uye cholesterol nekusunga kune receptor inozivikanwa sePPAR-Alpha (Peroxisome proliferator-activated receptor alpha).
Kuonekwa: White powder

 

Oleoylethanolamide (OEA) (111-58-0) NMR Spectrum

Oleoylethanolamide (OEA) (111-58-0) - NMR Spectrum

Kana iwe uchida COA, MSDS, HNMR kune rimwe nerimwe batch yechigadzirwa uye rumwe ruzivo, ndapota nyorera vedu mutengesi wekushambadzira.

 

Chii chinonzi Oleoylethanolamide (OEA) CAS 111-58-0?

Oleoylethanolamine (OEA) ndeyezvisikwa kuitika ethanolamide lipid uye nyukiliya receptor peroxisome proliferator-activated receptor-α (PPAR-α) agonist. Iyo inogadzirwa mudumbu diki uye inhibitisa chikafu chekudya kuburikidza nePPAR-α activation. OEA inoshandisawo GPR119, bioactive lipid ine hypophagic uye anti-kufutisa mhedzisiro.

 

Oleoylethanolamide (OEA) CAS 111-58-0 mabhenefiti

Oleoylethanolamide (OEA) ndeyemusikirwo metabolite iyo inogadzirwa mune mashoma mudumbu rako diki. OEA inobatsira kudzora nzara, uremu, mafuta emuviri uye cholesterol nekusunga kune receptor inozivikanwa sePPAR-Alpha (Peroxisome proliferator-activated receptor alpha). Mukukosha, OEA inowedzera metabolism yemafuta emuviri uye inotaurira uropi hwako kuti iwe uzere uye inguva yekumira kudya. OEA inozivikanwa zvakare kuwedzera isina-kurovedza zvinoenderana ne calorie mari.

 

Oleoylethanolamide (OEA) CAS 111-58-0 Mechanism Yekuita?

Oleoylethanolamide (OEA) inogadzirwa uye yakaunganidzwa muhunhu hudiki hunobvira kubva mukudya-inotorwa oleic acid, senge maorivhi emuorivhi. Kudya-kwemafuta kudya kunogona kutadzisa kugadzirwa kweOEA mumatumbu. OEA inoderedza kudya kwekudya nekumisikidza homeostatic oxytocin uye histamine brain circry pamwe nehedonic dopamine nzira. Pane humbowo hwekuti OEA inogona zvakare kudzikisira hedonic cannabinoid receptor 1 (CB1R) siginecha, iko kushandiswa kwayo kunoenderana nekuwedzera kudya kwekudya. OEA inoderedza kutakura kwemapididipidhi muadipocyte kudzikisa mafuta mashoma. Kuwedzera kujekeswa kwemhedzisiro yeOEA pakudya chikafu uye lipid metabolism ichabatsira mukumisikidza nzira dzehupenyu dzinogona kutariswa kukudziridza zvakanyanya kufutisa kurapa.

Oleoylethanolamide (OEA) ndeye agonist weperooxisome proliferator-activated receptor-α (PPAR-α). N-Oleoylethanolamide inogadzira chiratidzo chemuviri chinosimudzira pakati dopamine chiitiko chinosimbisa chinongedzo pakati pekoriori-homeostatic uye hedonic-vatungamiriri vekumba. Oleoylethanolamide yakaverengerwa senge mamorekuru mashandiro ane chekuita negastric bypass kubudirira. N-Oleoylethanolamide inosarudza GPR55 agonist.

 

Oleoylethanolamide (OEA) CAS 111-58-0 kunyoresa

Oleoylethanolamide (OEA) inoshanda kumisikidza chimwe chinhu chinonzi PPAR uye panguva imwe chete inokwidza kupisa-mafuta uye inoderedza kuchengetwa kwemafuta. Paunodya, OEA mazinga anowedzera uye chishuwo chako chinodzikira kana tsinga dzetsinga dzinobatanidza kuhuropi hwako dzichiudza kuti iwe waguta. PPAR-α iboka re-ligand-activated nyukireyori inogamuchira iyo inobatanidzwa mukutaura kwegene lipid metabolism uye energyhomeostasis nzira.

 

OEA upfu Sale(Kupi Kwekutenga Oleoylethanolamide (OEA) upfu muhuwandu)

Kambani yedu inonakidzwa nehurefu hwehukama nevatengi vedu nekuti tinotarisa pakubata kwevatengi nekupa zvigadzirwa zvikuru. Kana iwe unofarira chigadzirwa chedu, isu tinoshanduka pamwe neyakagadziriswa yemirairo kuti ikwane yako chaiyo yekuda uye yedu yekukurumidza kutungamira nguva pamirairo inovimbisa kuti uchave nekuravira kwedu kukuru chigadzirwa pane-nguva. Isu tinotarisawo pamabasa akawedzerwa-kukosha. Isu tinowanikwa yemibvunzo yebasa uye ruzivo rwekutsigira rako bhizinesi.

Isu tiri nyanzvi Oleoylethanolamide (OEA) mupfu mupi wekutengesa kwemakore akati wandei, isu tinopa zvigadzirwa nemakwikwi mutengo, uye chigadzirwa chedu chiri chemhando yepamusoro uye chinoenda kuomarara, kuyedza yakazvimirira kuona kuti yakachengeteka kudyiwa pasirese.

 

References

  1. Gaetani S, Oveisi F, Piomelli D (2003). "Kuchinja-famba kwemaitiro echikafu mumakonzo neanorexic lipid muyananisi oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311-6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  2. Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Mutemo wekudya unodyiwa ne oleoylethanolamine". Sero. Mol. Hupenyu Sci. 62 (6): 708-16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  3. Gaetani S, Kaye WH, Cuomo V, Piomelli D (Gunyana 2008). "Basa reendocannabinoids uye zvakafanana navo mukufutisa uye kusagadzikana kwekudya". Idya Kurema Kwehuremu. 13 (3): e42-8. PMID 19011363.