Nicotinamide Riboside Chloride (NR) (23111-00-4) Vagadziri - Cofttek

Nicotinamide Riboside Chloride (NR) (23111-00-4)

April 7, 2020

Nicotinamide riboside, inozivikanwawo seNR uye SRT647, iri pyridine-nucleoside fomu yevhitamini B3 inoshanda seamberi kweinicotinamide adenine dinucleotide kana NAD +. NR inovhara kuora kwemanyoka akavezwa dorsal midzi ganglion neurons ex vivo uye inochengetedza kubva kuruzha-rwakarerekera kunzwa kurasikirwa mune mbeva dzinorarama.


Mamiriro: MuMitambo Yokugadzira
Unit: 25kg / Drum

Nicotinamide Riboside Chloride (NR) (23111-00-4) vhidhiyo

Nicotinamide Riboside Chloride (NR) Specifications

Name: Nicotinamide Riboside Chloride (NR)
CAS: 23111-00-4
Purity 98%
Molecular Formula: C11H15ClN2O5
Molecular Weight: 290.7 g / mol
Melt Point: 115-125 ° C
Kemikari zita: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Synonyms: Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, α / β musanganiswa
InChI Key: YABIFCKURFRPPO-FSDYPCQHSA-N
Hafu Hupenyu: 2.7 maawa
Solubility: Soluble muDMSO, Methanol, Mvura
Chengetedzo Chimiro: 0 - 4 C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 C kwenguva refu (mwedzi)
Application: Nicotinamide riboside inonzi ndiyo fomu nyowani pyridine-nucleoside yevhitamini B₃ inoshanda seamberi kune nicotinamide adenine dinucleotide kana NAD +.
Kuonekwa: Off chena kuPale Yero upfu

Chii chinonzi Nikotinamide Riboside Chloride (NR) CAS 23111-00-4?

Nicotinamide riboside, inozivikanwawo seNR uye SRT647, iri pyridine-nucleoside fomu yevhitamini B3 inoshanda seamberi kweinicotinamide adenine dinucleotide kana NAD +. NR inovhara kuora kwemanyoka akavezwa dorsal midzi ganglion neurons ex vivo uye inochengetedza kubva kuruzha-rwakarerekera kunzwa kurasikirwa mune mbeva dzinorarama. Nicotinamide riboside inodzivirira tsandanyama, neural uye melanocyte stem cell senescence. Kuwedzerwa kwekusandukazve kwetsandanyama mune mbeva kwave kucherechedzwa mushure mekurapwa nicotinamide riboside, zvichitungamira kufungidzira kuti inogona kuvandudza kudzoreredzwa kwemitezo yakaita seiropa, itsvo, nemoyo. Nicotinamide riboside zvakare inoderedza glucose yeropa uye mafuta echiropa mu prediabetesic uye mhando 2 chirwere cheshuga apo ichidzivirira kukura kwechirwere cheshuga paripheral neuropathy. Ongorora: Nicotinamide Riboside chloride iri musanganiswa we α / β.

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 zvakanaka

Nicotinamide nucleoside ndeyekutanga kweiyo nicotinamide adenine dinucleotide (NAD) uye inomirira kunobva vitamini B3. Zvidzidzo zvichangobva kuratidzwa zvakaratidza kuti kutora muhuwandu hukuru we nikotidhiyidi zvakasikwa zviripo mune zvekudya kunogona kupa hutano hutsva hutano. Semuenzaniso, nicotinamide nucleosides yakave nekukanganiswa kuwedzera tishu NAD kusimbisa uye kukurudzira insulin kunzwa pamwe nekuwedzera sirtuin basa. Kugona kwayo kuwedzera NAD kugadzirwa kunoratidza kuti nicotinamide nucleosides inogonawo kuvandudza hutochondrial hutano, kukurudzira mitochondrial basa, uye kuitisa kugadzirwa kwemitochondria nyowani. Zvimwe zvidzidzo zvinoshandisa nicotinamide nucleosides muiyo chirwere cheAlzheimer chakaratidza kuti mamorekuru ari bioava kuwanikwa kuuropi uye anogona kupa neuroprotection nekumutsiridza uropi NAD synthesis.

Nicotinamide Riboside Chloride zvakare inogona Kuderedza uremu: Zvidzidzo zvakaratidza kuti nekuwedzera simba metabolism, unogona kunyatso kuderedza iyo yakanyanya-mafuta chikafu chinosimudzira uremu. Kuti uongorore iyo nicotinamide ribose maitiro eNR inosimudzira uremu, ivo vaongorori vakayera chiropa mitochondrial basa rakabatana ne caloric kudya, chiitiko, macalorie, chiuno kutenderera, kuzorora kwemetabolic rate, kuumbwa kwemuviri, glucose kushivirira, insulin kunzwa uye kwakasiyana biochemical uye metabolomics paramita. Idzi data uye hutsva huremu hwekurasikirwa uremu nem malabsorption, excretion yemakemikari emakemaki ekutevera. Vaongorori vacho vakareva kuti makonzo akapihwa nicotinamide nicotinamide anowedzerawo zvakanyanya kurasikirwa nehuremu kubva kune mbeva iyo isingawedzere nicotinamide

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Mechanism Yekuita?

Nicotinamide Riboside Chloride (NR) nucleosides ari pamberi peiyo nicotinamide adenine dinucleotide (NAD) uye anomiririra kunobva vhitamini B3. Zvidzidzo zvichangobva kuratidzwa zvakaratidza kuti kutora muhuwandu hukuru we nikotidhiyidi zvakasikwa zviripo mune zvekudya kunogona kupa hutano hutsva hutano. Semuenzaniso, nicotinamide nucleosides yakave nekukanganiswa kuwedzera tishu NAD kusimbisa uye kukurudzira insulin kunzwa pamwe nekuwedzera sirtuin basa. Kugona kwayo kuwedzera NAD kugadzirwa kunoratidza kuti nicotinamide nucleosides inogonawo kuvandudza hutochondrial hutano, kukurudzira mitochondrial basa, uye kuitisa kugadzirwa kwemitochondria nyowani. Zvimwe zvidzidzo zvinoshandisa nicotinamide nucleosides mune yechirwere cheAlzheimer chirwere chakaratidza kuti mamorekuru ari bioava kuwanikwa kuuropi uye anogona kupa neuroprotection nekumutsidzira uropi NAD synthesis ..

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 kunyoresa

Zvidzidzo zvepakutanga zvakaratidza kuti kuwedzerwa kwe nicotinamide ribose hakugone kungowedzera maNAD + zvakachengeteka, asi zvakare kukudza kushandiswa kweNAD + muvanhu, izvo zvisingaite pamwe neivitamin B3.Studies yakaratidza kuti kamwe nicotinamide ribose inoonekwa muchitokisi, iyo muviri unokurumidza kuchishandura kuita NAD +. Idzi NAD + dzinobva dzasimudzira maitiro e intracellular yekutanga kwesimba kugadzirwa nemitochondria

Nicotinamide Riboside Chloride inogona kukwidziridza mitochondrial basa, iyo inoratidzwa kuwedzera mushumo we mitochondrial elekitori yekutengesa mapuroteni emaketeni, kusimbisa mitochondrial membrane mukana, uye kuwedzera huwandu hweiyo oxidative kufema uye intracellular ATP mazinga. Izvi zvinogona kuperekedzwa neakakwira mazinga emamochondrial kubereka. Mitochondrial basa rinoderera sezvatino zera, uye ichi chiratidzo chechikuru chemasero emadzinde atinowana. NR inogona kuvandudza basa remitochondria uye inhibit iyo senescence yemasero emadziro.

Nicotinamide Riboside Chloride (NR) powder Sale(Iko Kutenga Nicotinamide Riboside Chloride (NR) poda muhuwandu)

Kambani yedu inonakidzwa nehurefu hwehukama nevatengi vedu nekuti tinotarisa pakubata kwevatengi nekupa zvigadzirwa zvikuru. Kana iwe unofarira chigadzirwa chedu, isu tinoshanduka pamwe neyakagadziriswa yemirairo kuti ikwane yako chaiyo yekuda uye yedu yekukurumidza kutungamira nguva pamirairo inovimbisa kuti uchave nekuravira kwedu kukuru chigadzirwa pane-nguva. Isu tinotarisawo pamabasa akawedzerwa-kukosha. Isu tinowanikwa yemibvunzo yebasa uye ruzivo rwekutsigira rako bhizinesi.

Isu tiri nyanzvi Nicotinamide Riboside Chloride (NR) poda mutengesi wemakore akati wandei, isu tinopa zvigadzirwa nemakwikwi emutengo, uye chigadzirwa chedu chemhando yepamusoro uye chinoedzwa chakasimba, chakazvimirira kuyedza kuti ive yakachengeteka kuti ishandiswe pasi rese.

References

  • Chi Y, Sauve AA. Nicotinamide riboside, inoteedzera zvinovaka zvinovaka mukudya, ivhitamini B3 ine zviga zvine simba metabolism uye neuroprotection. Curr Opin Clin Nutr Metab Care. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Ongorora. PubMed PMID: 24071780.
  • Bogan KL, Brenner C. Nicotinic acid, nicotinamide, uye nicotinamide riboside: kuongororwa kwemolesi yeiyo NAD + preursor mavitamini muhutano hwevanhu. Annu Rev Nutr. 2008; 28: 115-30. Doi: 10.1146 / annurev.nutr.28.061807.155443. Ongorora. PubMed PMID: 18429699.
  • Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation sesero-intrinsic, shanduko yemutyairi wekuchengetedza mafuta: chemakemikari uye metabolic logic yeacetyl-lysine moditions. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. Doi: 10.3109 / 10409238.2013.838204. Ongorora. PubMed PMID: 24050258; PubMed Pakati PMCID: PMC4113336.
  • Zvese zvaunoda Kuti Uzive NezveNicotinamide Riboside Chloride