Alpha Lipoic Acid (ALA)

April 20, 2021

Cofttek ndiyo yakanakisa Alpha Lipoic Acid (ALA) inogadzira poda muChina. Fekitori yedu ine yakakwana yekugadzira manejimendi system (ISO9001 & ISO14001), iine pamwedzi yekugadzira inokwana 1000kg.

 


Mamiriro: MuMitambo Yokugadzira
Unit: 1kg / bhegi, 25kg / Drum

Alpha Lipoic Acid (ALA) (1077-28-7) Specifications

Name: Alpha Lipoic Acid (ALA)
CAS: 1077-28-7
Purity 98%
Molecular Formula: C8H14O2S2
Molecular Kurema: 206.33 g / mol
Melt Point: 60-62 ° C (140-144 ° F; 333-335 K)
Kemikari zita: (R) -5- (1,2-Dithiolan-3-yl) pentanoic acid;

α-Lipoic asidhi; Alpha lipoic asidhi; Thioctic asidhi; 6,8-Dithiooctanoic acid

Synonyms: (±) -α-Lipoic acid, (±) -1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, DL -α-Lipoic acid, DL -6,8-Thioctic acid, Lip (S2 )
InChI Key: AGBQKNBQESQNJD-UHFFFAOYSA-N
Hafu Hupenyu: Hafu yehupenyu yeanotaurwa nemuromo ALA ingori 30 min
Solubility: Zvishoma nezvishoma Soluble mumvura (0.24 g / L); Solubility mune ethanol 50 mg / mL
Chengetedzo Chimiro: 0 - 4 C kwenguva pfupi (mazuva kusvika kumavhiki), kana -20 C kwenguva refu (mwedzi)
Application: Alpha-lipoic acid inoshandiswa mumuviri kuputsa makabhohaidhiretsi uye kugadzira simba rezvimwe nhengo mumuviri. Alpha-lipoic acid inoita kunge inoshanda se antioxidant, zvinoreva kuti inogona kudzivirira kuuropi pasi pemamiriro ekukuvara kana kukuvara.
Kuonekwa: Yero yeyero-yakafanana nemakristasi

 

Alpha Lipoic Acid (ALA) (1077-28-7) NMR Spectrum

 

Alpha Lipoic Acid (ALA) (1077-28-7) - NMR Spectrum

Kana iwe uchida COA, MSDS, HNMR kune rimwe nerimwe batch yechigadzirwa uye rumwe ruzivo, ndapota nyorera vedu mutengesi wekushambadzira.

 

Alpha Lipoic Acid (ALA) (1077-28-7)?

Alpha-lipoic acid ikomboni inowanikwa zvakasikwa mukati mega sero remuviri wemunhu. Basa rayo rekutanga kushandura shuga yeropa (glucose) kuita simba uchishandisa oxygen, maitiro anonzi aerobic metabolism. Alpha-lipoic acid inoonekwawo se antioxidant, zvichireva kuti inogona kudzikisira makomputa anokuvadza anonzi emahara radicals ayo anokuvadza maseru padanho regeneti.

Chii chinoita kuti alpha-lipoic acid ive yakasarudzika ndeyekuti inosungunuka mukati memvura nemafuta. Izvi zvinoreva kuti inogona kuendesa simba nekukasira kana kuichengetera kuti ishandiswe mune ramangwana.

Alpha-lipoic acid inogona zvakare kushandisa “akashandisa” antioxidants, anosanganisira vhitamini C, vhitamini E, uye ane simba amino acid yakakomberedzwa inozivikanwa se glutathione.1 Chero nguva izvi antioxidants zvadzikisira rusununguko rusununguko, zvinodzikamisa uye kuva vakasununguka radicals pachavo. Alpha-lipoic acid inobatsira kuvadzorera nekutora maerekitironi akawandisa uye nekuvashandura kumusana kune yavo yakagadzikana fomu.

Alpha-lipoic acid dzimwe nguva inotorwa sechiwedzero pasi pekufungidzira inogona kugadzirisa mamwe mashandiro emagetsi, kusanganisira kupisa mafuta, kugadzirwa kwecollagen, uye kudzora kweropa glucose. Pane humbowo huri kukura hwezvimwe zvezvikumbiro izvi.

 

Alpha Lipoic Acid (ALA) (1077-28-7) mabhenefiti

chirwere cheshuga

Yakagara ichifungidzirwa kuti alpha-lipoic acid inogona kubatsira mukutonga kweshuga nekuwedzera kumhanya uko shuga yeropa inogadziriswa. Izvi zvinogona kubatsira mukurapa chirwere cheshuga, chirwere chinoonekwa neasina kukwirira glucose mazinga.

Ongororo ye2018 yakarongeka uye meta-ongororo yemakumi maviri eakaedzwa akayedzwa miedzo yevanhu vane chirwere cheshuga (vamwe vaive nerudzi rwechipiri chirwere cheshuga, vamwe vaine zvimwe zvinokanganisa metabolic) vakaona kuti lipoic acid yekuwedzera inodzikisa kutsanya kweropa glucose, insulin insulin, insulin insulin, uye ropa hemoglobin A20C mazinga.

 

Tsinga kurwadziwa

Neuropathy izita rekurapa rinoshandiswa kurondedzera kurwadziwa, chiveve, uye kusanzwisisika kwekunzwa kunokonzerwa nekukuvara kwenzara. Kazhinji, kukanganisa kunokonzerwa nekushushikana kweiyo oxidative inoiswa pamitsipa nezvirwere zvisingaperi senge chirwere cheshuga, chirwere cheLyme, shingles, chirwere chetachiona, itsvo kutadza, uye HIV.

Zvinotendwa nevamwe kuti alpha-lipoic acid, yakapihwa muhombe doses yakakwana, inogona kupokana nekushushikana uku nekuita zvine simba antioxidant chiitiko. Pakave nehumbowo hweichi chiitiko kune vanhu vane chirwere cheshuga neuropathy, chinogona kukanganisa mamiriro akasangana nevanhu vane chirwere cheshuga chemberi.

Ongororo ya2012 yezvidzidzo kubva kuNetherlands yakagumisa kuti zuva nezuva mazana matanhatu emazana-mg intravenous dose yealpha-lipoic acid yakapihwa kwevhiki nhatu yakapa "kuderedzwa kwakakosha uye kwehutano pakurwadziwa kweuropathic."

Sezvakaitwa nezvidzidzo zvekare zvechirwere cheshuga, zvemumuromo alpha-lipoic acid zvinowedzera zvaiwanzove zvisinganyanyo shanda kana kusava nebasa zvachose.

 

Kuonda

Alpha-lipoic acid kugona kwekusimudzira macalorie kupisa uye kusimudzira uremu kwave kuwedzeredzwa nevazhinji vekudya gurus uye vanowedzera vagadziri. Nezvo izvo zvataurwa, pane humbowo huri kukura hwekuti alpha-lipoic acid inogona kukanganisa huremu, kunyangwe zvine mwero.

Ongororo ya2017 yezvidzidzo kubva kuYale University yakawana kuti alpha-lipoic acid inowedzera, iri muyero kubva pa300 kusvika pa1,800 mg zuva nezuva, yakabatsira kukurumidza kuperesa huremu hwekurasikirwa kwemapaundi 2.8 uchienzaniswa neiyo placebo.

Pakange pasina chekubatana pakati pe alpha-lipoic yekuwedzera dosi uye huwandu hwekuremerwa uremu. Zvakare, iyo nguva yekurapa inoita kunge inokanganisa muviri wemunhu index (BMI), asi kwete huremu hwemunhu chaihwo.

Zvinoreva izvi ndezvekuti, nyangwe zvichiratidzika iwe unogona chete kurasikirwa huremu hwakawanda nealpha-lipoic acid, muviri wako kuumbika kunogona kuvandudza sezvo mafuta achitsiviwa zvishoma nezvishoma neakaonda mhasuru.

 

High Cholesterol

Alpha-lipoic acid yakagara ichitendwa kuti inokanganisa huremu uye hutano nekushandura iyo lipid (mafuta) kuumbika muropa. Izvi zvinosanganisira kuwedzera "zvakanaka" high-density lipoprotein (HDL) cholesterol uchidzikisa "yakaipa" yakaderera-density lipoprotein (LDL) cholesterol uye triglycerides. Ongororo ichangobva kuitika inoratidza kuti izvi zvinogona kunge zvisina kudaro.

Mune ongororo ya2011 yakabva kuKorea, vanhu zana negumi nevasere vakapa 180 kusvika 1,200 mg yealpha-lipoic acid yakarashika makumi maviri muzana muzana huremu hwakawanda kupfuura boka re placebo mushure memasvondo makumi maviri asi havana kuwana kuvandudzwa kwecholesterol yakazara, LDL, HDL, kana triglycerides.

Naizvozvo, mwero yakakwira yealpha-lipoic acid yakapihwa kuwedzera muhuwandu hwecholesterol neLDL muvatori vechikamu vechidzidzo.

 

Ganda Rakuvara Zuva

Vagadziri veCosmetics vanowanzofarira kuzvirumbidza kuti zvigadzirwa zvavo zvinobatsira kubva kune "anti-kuchembera" zvimiro zvealpha-lipoic acid. Tsvagiridzo inoratidza kuti panogona kuve nekutenda kune izvi zvirevo. Chinyorwa chekudzokorora chinoratidza kuti ine antioxidant ine simba uye yakadzidzwa nekuda kwekudzivirira kwayo kukuvadzwa nemwaranzi.

 

Alpha Lipoic Acid (ALA) (1077-28-7) tizvishandise?

Alpha-lipoic acid kana ALA chinhu chinowanzoitika chinogadzirwa mumuviri. Iyo inoshanda yakakosha mabasa padanho remaseru, senge kugadzirwa kwesimba. Chero bedzi iwe uine hutano, muviri unogona kuburitsa yese iyo ALA yainoda nekuda kwezvinangwa izvi. Kunyangwe hazvo chokwadi, pange paine zvakawanda zvekuchangobva kufarira kushandisa ALA zvinowedzera. Vanotsigira ALA vanoita zvirevo zvinotangira pamigumisiro yekurapa mamiriro akaita seshuga neHIV mukusimudzira kuonda.

 

Alpha Lipoic Acid (ALA) (1077-28-7) Dosage

Ipo ichinzi yakachengeteka, hapana nongedzo inotungamira kushandiswa kwakakodzera kwealpha-lipoic acid. Mazhinji ekuwedzera emuromo anotengeswa mumafomati anotangira pa100 kusvika 600 mg. Zvichienderana neakawanda ehuchapupu hwazvino, yakanyanya zuva nezuva dhizaini inosvika 1,800 mg inofungidzirwa kuve yakachengeteka muvakuru.

Nezvo izvo zvataurwa, zvese kubva pahuremu hwemuviri uye zera kusvika kuchiropa kushanda uye itsvo basa zvinogona kukanganisa zvakachengeteka kwauri semunhu. Semutemo wakazara wechigunwe, kukanganisa parutivi rweyambiro uye gara uchisarudza dosi repasi.

Alpha lipoic acid inowedzera inogona kuwanikwa pamhepo uye munzvimbo zhinji dzezvitoro zvekudya uye zvitoro zvemishonga. Zvekuwandisa kuwanda, zvinowedzerwa zvinofanirwa kutorwa pasina chinhu mudumbu.

 

Alfa-lipoic Acid poda Sale(Kwokutenga Alfa-lipoic Acid poda yakawanda)

Kambani yedu inonakidzwa nehurefu hwehukama nevatengi vedu nekuti tinotarisa pakubata kwevatengi nekupa zvigadzirwa zvikuru. Kana iwe unofarira chigadzirwa chedu, isu tinoshanduka pamwe neyakagadziriswa yemirairo kuti ikwane yako chaiyo yekuda uye yedu yekukurumidza kutungamira nguva pamirairo inovimbisa kuti uchave nekuravira kwedu kukuru chigadzirwa pane-nguva. Isu tinotarisawo pamabasa akawedzerwa-kukosha. Isu tinowanikwa yemibvunzo yebasa uye ruzivo rwekutsigira rako bhizinesi.

Isu tiri nyanzvi yeAlfa-lipoic Acid poda mupiki wemushonga kwemakore akati wandei, isu tinopa zvigadzirwa nemutengo wemakwikwi, uye chigadzirwa chedu chiri chemhando yepamusoro uye chinoenda mukuomarara, kwakazvimirira kuyedzwa kuona kuti yakachengeteka kudyiwa pasirese.

 

References

  1. Haenen, GRMM; Bast, A (1991). "Kubvarura hypochlorous acid ne lipoic acid". Biochemical Pharmacology. 42 (11): 2244-6. doi: 10.1016 / 0006-2952 (91) 90363-A. PMID 1659823.
  2. Biewenga, Chiremba; Haenen, GR; Bast, A (Gunyana 1997). "Iyo pharmacology yeiyo antioxidant lipoic acid". General Chemishonga. 29 (3): 315-31. doi: 10.1016 / S0306-3623 (96) 00474-0. PMID 9378235.
  3. Schupke, H; Hempel, R; Peter, G; Hermann, R; et al. (Chikumi 2001). "Nzira nyowani dzemagetsi dzealpha-lipoic acid". Zvinodhaka Metabolism uye Disposition. 29 (6): 855-62. PMID 11353754.
  4. Acker, DS; Wayne, WJ (1957). "Inoshanda uye radioactive α-lipoic acids". Zvinyorwa zveAmerican Chemical Society. 79 (24): 6483-6487. doi: 10.1021 / ja01581a033.
  5. Hornberger, CS; Heitmiller, RF; Gunsalus, IC; Schnakenberg, GHF; et al. (1952). "Kugadzirira kwekugadzira lipoic acid". Zvinyorwa zveAmerican Chemical Society. 74 (9): 2382. doi: 10.1021 / ja01129a511.