NMN upfu (1094-61-7)

April 7, 2020

Cofttek ndiyo yakanakisa inogadzira hupfu hweNMN muChina. Fekitori yedu ine yakakwana yekugadzira manejimendi system (ISO9001 & ISO14001), iine pamwedzi yekugadzira inokwana 2400kg.

 


Mamiriro: MuMitambo Yokugadzira
Unit: 1kg / bhegi, 25kg / Drum

NMN upfu (1094-61-7) Video

 

NMN poda Specifications

Name: β-Nicotinamide Mononucleotide (NMN)
CAS: 1094-61-7
Purity 98%
Molecular Formula: C11H15N2O8P
Molecular Kurema: 334.2208 g / mol
Melt Point: > 96 ° C
Kemikari zita: ((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate
Synonyms: Nicotinamide Mononucleotide; NMN; β-NMN; β -Nicotinamide mononucleotide
InChI Key: DAYLJWODMCOQEW-TURQNECASA-N
Hafu Hupenyu: N / A
Solubility: Soluble muDMSO, Methanol, Mvura
Chengetedzo Chimiro: 0 - 4 C kwenguva pfupi (mazuva kusvika kumavhiki), kana -20 C kwenguva refu (mwedzi)
Application: Nicotinamide mononucleotide (NMN) inobuda yeB-vitamini niacin iyo inovandudza zvikuru hutano uye hupenyu hwakareba nekushanda sehuremu hweNAD +, kenduru inoita basa rakakosha mukugadzirwa kwesimba, metabolism, uye gene expression mumuviri.
Kuonekwa: White powder

 

NMN (1094-61-7) NMR Spectrum

NMN (1094-61-7) - NMR Spectrum

Kana iwe uchida COA, MSDS, HNMR kune rimwe nerimwe batch yechigadzirwa uye rumwe ruzivo, ndapota nyorera vedu mutengesi wekushambadzira.

 

Chii chinonzi β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7?

Nicotinamide Mononucleotide, inozivikanwawo se ("NMN" uye "β-NMN") inonzi nucleotide inotorwa kubva ku ribose uye nicotinamide Senge nicotinamide riboside, NMN inotorwa ne niacin, uye vanhu vane maenzymes anogona kushandisa NMN kuburitsa nicotinamide adenine dinucleotide ( NADH). Nekuti NADH inoratidzira maitiro mukati memitochondria, sirtuin, uye PARP, NMN yakadzidzwa mumhando dzemhuka senge inogona neuroprotective uye anti-kukwegura mumiriri.

 

β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 mabhenefiti

Kutsvaga-kukwegura kutsvaga kwakaratidza kuti kuwedzeredza neNMN, kiyi NAD + yepakati, inoshanda mukuderedza makore anoenderana neyakaitika metabolic kuderera uye kudzora kufambira mberi kwehuwandu hwezvirwere zvine chekuita nezera. NMN ine mhedzisiro inobatsira mukugadzirwa kwesimba panzvimbo yemaseroji, inovandudza kushivirira glucose, inoderedza kuzvimba, inobatsira kuchengetedza zvinotenderera, inogadzirisa DNA, uye ine mhedzisiro inobatsira pakuchengetwa kwekuziva kwebasa. NMN yakaratidzawo zvingangoita seanorapa mumiririri kupesana neanodegenerative kusagadzikana kunoenderana nechembere. Kuwedzerwa neNMN kunogona kubatsira pakuchengetedza kutsungirira uye kufamba. Kuchengetedza mabasa eaya akasiyana masisitimu mumuviri wese kunosimudzira hutano uye hupenyu hwakareba uye nekunyatsogadzirisa hupenyu hwehupenyu sezvo kukwegura kuchifambira mberi.

 

β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 Mechanism Yekuita?

β-Nicotinamide Mononucleotide (NMN) iri pakati NAD + biosynthesis inogadzirwa kubva nicotinamide kuburikidza nicotinamide phosphoribosyltransferase (NAMPT) uye inonziwo NMN kana nicotinamide ribotide. Mune ongororo dzichangobva kuitwa dzekushandisa kweNMN kudzivirira uye kuongororwa kwezvirwere zvinoenderana nezera rakadai seshuga, neurodegenerative kusagadzikana, chirwere chemwoyo nezvimwe, yave imwe yeanopisa biomarkers panhaurirano yekurwisa kukwegura, nguva pfupi yadarika.

 

β-Nicotinamide Mononucleotide (NMN) CAS 1094-61-7 kunyoresa

β-Nicotinamide Mononucleotide (NMN) ine zvayakanakira metabolism mumuviri wese, kusanganisira zvirinani mumabhonzo emapfupa, kushaya chiropa, kushomeka kwemapfupa, ziso remaziso, insulin kunzwa, kushanda kwemuviri, huremu hwemuviri, uye nhanho dzekuita.

 

NMN powder Sale(Iko Kutenga β-Nicotinamide Mononucleotide (NMN) poda muhuwandu)

Kambani yedu inonakidzwa nehurefu hwehukama nevatengi vedu nekuti tinotarisa pakubata kwevatengi nekupa zvigadzirwa zvikuru. Kana iwe unofarira chigadzirwa chedu, isu tinoshanduka pamwe neyakagadziriswa yemirairo kuti ikwane yako chaiyo yekuda uye yedu yekukurumidza kutungamira nguva pamirairo inovimbisa kuti uchave nekuravira kwedu kukuru chigadzirwa pane-nguva. Isu tinotarisawo pamabasa akawedzerwa-kukosha. Isu tinowanikwa yemibvunzo yebasa uye ruzivo rwekutsigira rako bhizinesi.

Isu tiri nyanzvi β-Nicotinamide Mononucleotide (NMN) mutengesi wehupfu kwemakore akati wandei, isu tinopa zvigadzirwa nemakwikwi emutengo, uye chigadzirwa chedu chemhando yepamusoro uye chinoedzwa chakasimba, chakazvimirira pakuyedza kuti ive yakachengeteka kuti ishandiswe pasi rese.

 

References

  • Kiss T, Balasubramanian P, Valcarcel-Ares MN, Tarantini S, Yabluchanskiy A, Csipo T, Lipecz A, Reglodi D, Zhang XA, Bari F, Farkas E, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) kurapa kunosimbisa oxidative kushushikana. uye inonunura angiogenic simba mune vakwegura cerebromicrovascular endothelial maseru: mukana unokwanisa kudzivirira wevascular cognitive impairment. Geroscience. 2019 May 29. doi: 10.1007 / s11357-019-00074-2. PubMed PMID: 31144244.
  • Lukacs M, Gilley J, Zhu Y, Orsomando G, Angeletti C, Liu J, Yang X, Park J, Hopkin RJ, Coleman MP, Zhai RG, Stottmann RW. Severe biallelic kurasikirwa-kwe-kushanda shanduko mu nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) muzvikamu zviviri zvine fetal akinesia defuction sequence. Expur Neurol. 2019 Chivabvu 25: 112961. doi: 10.1016 / j.expneurol.2019.112961.PubMed PMID: 31136762.
  • Grozio A, Mills KF, Yoshino J, Bruzzone S, Sociali G, Tokizane K, Lei HC, Cunningham R, Sasaki Y, Migaud ME, Imai SI. Slc12a8 iri nicotinamide mononucleotide transporter. Nat Metab. 2019 Jan; 1 (1): 47-57. doi: 10.1038 / s42255-018-0009-4. Epub 2019 Jan 7. PubMed PMID: 31131364; PubMed Pakati PMCID: PMC6530925.