α-ketoglutaric

Cofftek inokwanisa kugona kugadzirwa kwakawanda uye kupihwa kweCalcium 2-oxoglutarate uye Alpha-Ketoglutaric Acid pasi pemamiriro e cGMP.

Chii chinonzi Alpha-Ketoglutaric Acid (328-50-7)?

Alpha-ketoglutaric acid chinhu chinoberekwa chinowanikwa zvakasikwa mumuviri wemunhu. Iyo inowanikwawo sekuwedzera kwekudya, alpha-ketoglutaric acid inoita basa rakakosha muKrebs kutenderera (akateedzana emakemikari maitiro anoshandiswa kuburitsa yakachengetwa simba). Alpha-ketoglutaric acid zvinowedzera zvinofungidzirwa kuti zvinopa zvakasiyana siyana zvehutano mabhenefiti, kusanganisira akakwidziridzwa emitambo mashandiro uye nekuvandudza metabolism.

Alpha-Ketoglutaric Acid (328-50-7) mabhenefiti

Nezvo izvo zvataurwa, zvishomanana zvidzidzo zvekutanga zvakaratidza kune zvingangodaro zvinobatsira zvealpha-ketoglutaric acid supplementation. Izvi ndizvo zvinotaurwa nezvimwe zvekutsvaga izvozvi:
RonicChronic Kidney Zvirwere
Alpha-ketoglutaric acid yanga ichishandiswa kubvira mukunopera-1990s kubatsira kuputsa uye kutora mapuroteni mune vanhu vari pahemodialysis vanoda yakaderera-protein chikafu. Huchangobva humbowo hunoratidza kuti zvinogona zvakare kunonotsa kudiwa kwe dialysis mune vanhu vane chirwere chemberi cheitsvo (CKD). Maererano neongororo ya2017 mumagazini PLoS One, vatsvagiridzi vakaona uye vakatevera vanhu 1,483 vane CKD yemhando yepamusoro avo vaishandisa alpha-ketoglutaric acid yekuwedzera inonzi Ketosteril. Ivhareji yenguva yekutevera yaive makore 1.57. Zvichienzaniswa neyakaenzana seti yevanhu vasina kutora chinowedzera, avo vakaita zvishoma mukana wekuda kwenguva refu dialysis. Iwo mabhenefiti akawedzeredzwa chete kune avo vakatora anopfuura mahwendefa e5.5 pazuva, zvichiratidza kuti mhedzisiro yacho yaitsamira padosi. Kunyangwe zviwanikwa zvakanaka, hazvizivikanwe kuti basa rei alpha-ketoglutaric acid rinotamba kana tichienzanisa neyekuwedzera yezvimwe zvinoshanda. Kuwedzera kutsvagurudza kunodiwa.

Hutano hwepamuviri
Alpha-ketoglutaric acid zvinowedzera zvinotendwa anticatabolic, zvichireva kuti inononoka kana kudzivirira kana catabolism (kuparara kwetishu). Nekutsanangurwa, maitiro ekugadzirisa anotarisana neanabolic maitiro (mune maturusi akavakwa). Chidzidzo che2012 muItaly Chinyorwa cheMhuka Sayenzi chakataura kuti alpha-ketoglutaric acid yakadzivirira kuparara kwematumbo mumakonzo emarabhoti akadyisa chikafu chisina mapuroteni kwemazuva gumi nemana. Panzvimbo pekuona kukuvara kumunwe-kunge villi yematumbo-mhedzisiro inotarisirwa-makonzo akadyisa alpha-ketoglutaric acid yakanga isina kukuvara kunoonekwa kana ichienzaniswa nemakonzo aive asiri. Zvakare, iwo makonzo akapa izvo zvekuwedzera zvaikwanisa kuchengetedza zvakajairika kukura kunyangwe kushomeka kwese kweprotein. Doses yepamusoro yakapihwa kune zvirinani zviripo. Zvakawanikwa zvinoita sekutsigira alpha-ketoglutaric acid's anticatabolic mhedzisiro. Kunze kwekushandisa kwaro mune chirwere chisingaperi cheitsvo, alpha-ketoglutaric acid inogona zvakare kubatsira vanhu vane intestinal toxemia uye malabsorption kusagadzikana senge chirwere chechiliac. Kuwedzera kutsvagurudza kunodiwa.

ThAtletic Performance
Kusiyana neizvi, anticatabolic mhedzisiro yealpha-ketoglutaric acid inoita kunge inodonha kana ichishandiswa nechinangwa chekukura kwemhasuru uye kuita kwemitambo. Zvinoenderana neongororo yakaitwa muna2012 muChinyorwa cheInternational Society of Sports Nutrition, alpha-ketoglutaric acid yakange isina chinobatika pamasimba emusimba kana kurovedza muviri muvarume gumi nevatanhatu vane basa rekuramba kudzidzira kurovedza muviri. Pachidzidzo ichi, hafu yevarume vakapiwa 16-milligrams (mg) yealpha-ketoglutaric acid, nepo imwe hafu yakapihwa placebo maminetsi makumi mashanu nemashanu vasati vaita bhenji rekutsikirira uye gumbo rekutsikirira. Vhiki raitevera, zvinowedzerwa zvakapetwa, hafu yega yega ichiwana mumwe mushonga. Athletic performance yaive yakavakirwa pane yakazara mutoro vhoriyamu (TLV) yezviratidziro zvinoitwa tandem ne pre- uye post-kurovedza moyo zviyero. Zvinoratidzwa nezvakawanikwa izvi kusavapo kwemhinduro dzemagetsi hachisi chinhu chakafanana nemhinduro yevanabolic, kunyanya pakati pevatambi.

Alpha-Ketoglutaric Acid (328-50-7) inoshandisa?

Mukuvhiya kwemoyo, alpha-ketoglutaric acid dzimwe nguva inoendeswa mukati (mukati mutsinga) kudzikisira kukuvara kwemhasuru yemoyo nekuda kwekudzikira kweropa. Kuita izvi kunogona zvakare kuvandudza kuyerera kweropa kuenda kuitsvo zvichitevera kuvhiyiwa. Kushandiswa kwaro sekuwedzera kuri kushoma chokwadi. Vamwe varapi vanotenda kuti alpha-ketoglutaric acid inogona kubata kana kudzivirira akasiyana mamiriro ehutano, kusanganisira:
  • Cataracts
  • Chirwere chisingaperi chepfungwa
  • Hepatomegaly (yakawedzera chiropa)
  • Utumbo toxemia
  • Oral thrush
  • Osteoporosis
  • Tendinopathy
  • Yeast matenda
Nekuda kwebasa rayo mukuburitsa rakachengetwa simba, alpha-ketoglutaric acid inowanzo kushambadzirwa semitambo yekuwedzera yekuwedzera. Vamwe vatsigiri vanototaura kuti iyo yekuwedzera antioxidant mhedzisiro inogona kunonoka kukwegura. Sezvazvinowanzoitika mune zvinowedzera izvo zvinoti zvinorapa akawanda mamiriro asina hukama, humbowo hunotsigira izvi zvirevo hauna simba. Zvimwe, senge zvinowedzerwa zve "anti-kuchembera" zvivakwa (zvichibva zvakanyanya pachidzidzo cha2014 chinosanganisira nematode honye), muganho pane zvisingafungidzike.

Alpha-Ketoglutaric Acid (328-50-7) muyero

Alpha-ketoglutaric acid inowedzera inowanika muhwendefa, kapsule, uye upfu mafomu uye inogona kuwanikwa zviri nyore pamhepo kana muzvitoro zvine hunyanzvi hwekudya. Iko hakuna kwepasirese nhungamiro yekushandisa kwakakodzera alpha-ketoglutaric acids. Zvekuwedzera zvinowanzo kutengeswa mumadosi kubva ku300 milligrams (mg) kusvika ku1,000 mg inotorwa kamwe chete pazuva kana pasina kana chikafu. Maitiro anosvika ku3,000 mg ave achishandiswa muzvidzidzo pasina mhedzisiro.

Alpha-Ketoglutaric Acid (328-50-7) inogona kuitika mhedzisiro

Alpha-ketoglutaric acid inoonekwa seyakachengeteka uye inoregererwa zvakanaka. Zvidzidzo zvichiongorora mhedzisiro yeAlpha-ketoglutaric acid yakaratidza mashoma mashoma mashure mushure memakore matatu ekushandisa. Sechinhu chakaumbwa kubva kune asiri-akakosha amino acids, alpha-ketoglutaric acid hachisi chinhu icho iwe chaunogona kuwandisa nyore. Chero chakawandisa mumuviri chingave chinoburitswa mumuti kana kuputswa muzvikamu zvekutanga zveamino acid kune zvimwe zvinangwa. Nezvo zvakati, kuchengetedzwa kwealpha-ketoglutaric acid mune vakadzi vane nhumbu, vanaamai vanoyamwisa, uye vana hakuna kusimbiswa. Izvi zvinosanganisira vana vasina kujairika metabolism kusagadzikana senge alpha-ketoglutarate dehydrogenase kushomeka (mune iyo alpha-ketoglutaric acid mazinga akasimudzwa zvisina kujairika).

Alpha-Ketoglutaric Acid poda iri kutengeswa (Kwaunga Tenga Alpha-Ketoglutaric Acid poda yakawanda)

Kambani yedu inonakidzwa nehukama hwakareba nevatengi vedu nekuti isu tinotarisana nebasa revatengi uye nekupa zvigadzirwa zvikuru. Kana iwe uchifarira chigadzirwa chedu, isu tinoshanduka-shanduka pamwe neyakagadziriswa mirairo kuti ienderane neyako chaiyo yekuda uye yedu inokurumidza kutungamira nguva pane mirairo inovimbisa iwe uchave nekuravira kukuru kwedu chigadzirwa pa-nguva. Isu tinotarisawo pane kukosha-kwakawedzerwa masevhisi. Isu tinowanikwa yemibvunzo yebasa uye ruzivo rwekutsigira bhizinesi rako. Isu tiri nyanzvi Alfa-Ketoglutaric Acid poda mupiki wemushonga kwemakore akati wandei, isu tinopa zvigadzirwa nemutengo wekukwikwidza, uye chigadzirwa chedu chiri chemhando yepamusoro uye chinoitwa nekuomarara, kuyedza yakazvimirira kuona kuti yakachengeteka kudyiwa pasirese.

Dheuteronomio:

  1. Abrahams JP, Leslie AG, Lutter R, Walker JE. Maumbirwo e2.8 Kugadziriswa kweF1-ATPase kubva kumombe yemoyo mitochondria. Zvisikwa. 1994; 370: 621-628. doi: 10.1038 / 370621a0.
  2. Alpers DH. Glutamine: ko iyo data inotsigira iyo chikonzero che glutamine yekuwedzera mune vanhu? Gastroenterology. 2006; 130: S106-S116. doi: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Muscle uye plasma amino acids zvichitevera kukuvara. Ann Kuvhiya. 1980; 192: 78-85. doi: 10.1097 / 00000658-198007000-00014.