α-ketoglutaric (328-50-7) (71686-01-6) - Mugadziri fekitori

α-ketoglutaric

Cofftek inokwanisa kugona kugadzirwa kwakawanda uye kupihwa kweCalcium 2-oxoglutarate uye Alpha-Ketoglutaric Acid pasi pemamiriro e cGMP.

Cofttek mureza

Tenga α-ketoglutaric poda

Dhaunirodha Resource

Chii chinonzi Alpha-Ketoglutaric Acid (328-50-7)?

Alpha-ketoglutaric acid chinhu chinoberekwa chinowanikwa zvakasikwa mumuviri wemunhu. Iyo inowanikwawo sekuwedzera kwekudya, alpha-ketoglutaric acid inoita basa rakakosha muKrebs kutenderera (akateedzana emakemikari maitiro anoshandiswa kuburitsa yakachengetwa simba). Alpha-ketoglutaric acid zvinowedzera zvinofungidzirwa kuti zvinopa zvakasiyana siyana zvehutano mabhenefiti, kusanganisira akakwidziridzwa emitambo mashandiro uye nekuvandudza metabolism.

Alpha-Ketoglutaric Acid (328-50-7) mabhenefiti

Nezvo izvo zvataurwa, zvishomanana zvidzidzo zvekutanga zvakaratidza kune zvingangodaro zvinobatsira zvealpha-ketoglutaric acid supplementation. Izvi ndizvo zvinotaurwa nezvimwe zvekutsvaga izvozvi:
RonicChronic Kidney Zvirwere
Alpha-ketoglutaric acid yakashandiswa kubva mukupera-1990s kubatsira kuputsa uye kutora mapuroteni muvanhu vari pahemodialysis vanoda kudya kwakaderera-protein. Humbowo huchangoburwa hunoratidza kuti inogonawo kunonoka kudiwa kwedialysis muvanhu vane chirwere cheitsvo chepamusoro (CKD).

(1)↗

Yakavimbika Tsime

PubMed Central

Inoremekedzwa dhatabhesi kubva kuNational Institutes of Health
Enda kunzvimbo

Zvinoenderana neongororo ya2017 mujenari PLoS One, vaongorori vakaona uye vakatevera vanhu 1,483 vane CKD yepamusoro avo vakashandisa alpha-ketoglutaric acid supplement inonzi Ketosteril. Avhareji yenguva yekutevera yaive makore 1.57.
Kuenzaniswa neseti yakaenzana yevanhu vasina kutora chekuwedzera, avo vakaita vaisanyanya kuda dialysis yenguva refu. Mabhenefiti akawedzerwa kune avo vakatora anopfuura mahwendefa e5.5 pazuva, zvichiratidza kuti mhedzisiro yacho yaienderana nedosi.
Zvisinei nezvakawanikwa zvakanaka, hazvizivikanwe kuti alpha-ketoglutaric acid yakaita sei mukuenzanisa nezvimwe zvekuwedzera zvinoshanda. Imwe tsvakurudzo inodiwa.

Hutano hwepamuviri
Alpha-ketoglutaric acid supplements inotendwa kuva anticatabolic, zvinoreva kuti inononoka kana kudzivirira kana catabolism (kuparara kwematishu). Netsanangudzo, iyo catabolic process inopesana neanabolic process (iyo inovakwa matishu).
Chidzidzo che 2012 muItaly Journal of Animal Science chakashuma kuti alpha-ketoglutaric acid yakadzivirira kuparara kwematumbo mumakonzo erabhoritari akadyisa kudya kusina mapuroteni kwemazuva gumi nemana. Panzvimbo pekusangana nekukuvadzwa kumunwe-kunge villi yeura - mhedzisiro inotarisirwa - makonzo akadyiswa alpha-ketoglutaric acid aive asina kukuvadzwa kunooneka zvichienzaniswa nemakonzo aive asiri.
Uyezve, makonzo akapa izvo zvinowedzera zvakakwanisa kuchengetedza kukura kwakajairika kunyangwe kushomeka kweprotein. Mishonga yepamusoro inopa mhedzisiro iri nani.
Zvakawanikwa zvinoita sezvinotsigira alpha-ketoglutaric acid's anticatabolic mhedzisiro. Pamusoro pekushandiswa kwayo muchirwere cheitsvo chisingaperi, alpha-ketoglutaric acid inogonawo kubatsira vanhu vane intestinal toxemia uye malabsorption kusagadzikana senge celiac chirwere. Imwe tsvakurudzo inodiwa.

ThAtletic Performance
Kusiyana neizvi, iyo anticatabolic mhedzisiro yealpha-ketoglutaric acid inoita seisina kupfupika kana ichishandiswa nechinangwa chekukura kwemhasuru uye kuita kwemitambo.
Maererano neongororo ya2012 muJournal yeInternational Society of Sports Nutrition, alpha-ketoglutaric acid yakanga isina mhedzisiro inobatika pasimba retsandanyama kana kushingirira muvarume gumi nevatanhatu vakapihwa basa rekudzivirira kudzidzisa.

(2)↗

Yakavimbika Tsime

PubMed Central

Inoremekedzwa dhatabhesi kubva kuNational Institutes of Health
Enda kunzvimbo

Nokuda kwechidzidzo ichi, hafu yevarume yakapiwa 3,000-milligrams (mg) yealpha-ketoglutaric acid, asi imwe hafu yakapiwa placebo 45 maminetsi vasati vaita mabhenji uye gumbo rekuita maitiro. Vhiki rakatevera racho, zvokuwedzera zvakachinjwa, hafu imwe neimwe ichiwana mumwe mushonga.
Kuita kwemumhanyi kwaive kwakavakirwa pahuwandu hwehuwandu hwehuwandu (TLV) hwemaekisesaizi akaitwa mu tandem ne pre- uye post-exercise moyo mitengo. Zvinoratidzwa izvi zvakawanikwa kusavapo kwekatabolic mhinduro haisi chinhu chakafanana nevanabolic mhinduro, kunyanya pakati pevatambi.

Alpha-Ketoglutaric Acid (328-50-7) inoshandisa?

Mukuvhiyiwa kwemoyo, alpha-ketoglutaric acid dzimwe nguva inounzwa mutsinga (mutsinga) kuderedza kukuvadzwa kwemhasuru yemoyo nekuda kwekuderera kwekuyerera kweropa. Kuita izvi kunogonawo kuvandudza kuyerera kweropa kuenda kuitsvo mushure mekuvhiyiwa.
Kushandiswa kwayo sekuwedzera kune chokwadi kushoma. Vamwe varapi vanotenda kuti alpha-ketoglutaric acid inogona kurapa kana kudzivirira hutano hwakasiyana siyana, kusanganisira:
  • Cataracts
  • Chirwere chisingaperi chepfungwa
  • Hepatomegaly (yakawedzera chiropa)
  • Utumbo toxemia
  • Oral thrush
  • Osteoporosis
  • Tendinopathy
  • Yeast matenda
Nekuda kwebasa rayo mukuburitsa simba rakachengetwa, alpha-ketoglutaric acid inowanzo tengeswa sekuwedzera kwemitambo. Vamwe vanotsigira vanototaura kuti iyo yekuwedzera antioxidant mhedzisiro inogona kunonoka kuchembera.

(3)↗

Yakavimbika Tsime

PubMed Central

Inoremekedzwa dhatabhesi kubva kuNational Institutes of Health
Enda kunzvimbo

Sezvinowanzoitika kune zvekuwedzera izvo zvinoti zvinorapa akawanda asina hukama mamiriro, humbowo hunotsigira izvi zvirevo hauna simba. Zvimwe, senge yekuwedzera "anti-kuchembera" zvivakwa (zvakavakirwa zvakanyanya paongororo ya2014 inosanganisira nematode worm), muganho pane zvisingaite.

Alpha-Ketoglutaric Acid (328-50-7) muyero

Alpha-ketoglutaric acid supplements inowanikwa muhwendefa, capsule, uye poda maumbirwo uye inogona kuwanikwa nyore nyore online kana muzvitoro zvinonyanya hunyanzvi hwezvekudya.
Iko hakuna mazano epasi rose ekushandiswa kwakakodzera kwealpha-ketoglutaric acids. Masupplement anowanzo kutengeswa mumadosi kubva ku300 milligrams (mg) kusvika ku1,000 mg inotorwa kamwe chete zuva nezuva kana pasina chikafu. Mishonga inosvika 3,000 mg yakashandiswa muzvidzidzo pasina mhedzisiro yakaipa.

Alpha-Ketoglutaric Acid (328-50-7) inogona kuitika mhedzisiro

Alpha-ketoglutaric acid inonzi yakachengeteka uye inoshivirirwa zvakanaka. Zvidzidzo zvekuongorora mhedzisiro yealpha-ketoglutaric acid yakataura zvishoma zviratidzo zvakashata mushure memakore matatu ekushandiswa.
Semusanganiswa wakagadzirwa kubva kune-asina kukosha amino acids, alpha-ketoglutaric asidhi haisi chinhu chaunogona kuwedzeredza. Chero kuwandisa kuri mumuviri kunozoburitswa muweti kana kuputswa kuita maamino acid ekuvaka zvidhinha kune zvimwe zvinangwa.

(4)↗

Yakavimbika Tsime

PubMed Central

Inoremekedzwa dhatabhesi kubva kuNational Institutes of Health
Enda kunzvimbo

Nezvakataurwa, kuchengetedzwa kwealpha-ketoglutaric acid muvakadzi vane pamuviri, vanaamai vanoyamwisa, uye vana hakuna kusimbiswa. Izvi zvinosanganisira vana vane isingawanzo metabolism kusagadzikana senge alpha-ketoglutarate dehydrogenase kushomeka (umo ma alpha-ketoglutaric acid mazinga akakwira zvisina mwero).

Alpha-Ketoglutaric Acid poda iri kutengeswa (Kwaunga Tenga Alpha-Ketoglutaric Acid poda yakawanda)

Kambani yedu inonakidzwa nehurefu hwehukama nevatengi vedu nekuti tinotarisa pakubata kwevatengi nekupa zvigadzirwa zvikuru. Kana iwe unofarira chigadzirwa chedu, isu tinoshanduka pamwe neyakagadziriswa yemirairo kuti ikwane yako chaiyo yekuda uye yedu yekukurumidza kutungamira nguva pamirairo inovimbisa kuti uchave nekuravira kwedu kukuru chigadzirwa pane-nguva. Isu tinotarisawo pamabasa akawedzerwa-kukosha. Isu tinowanikwa yemibvunzo yebasa uye ruzivo rwekutsigira rako bhizinesi.
Isu tiri nyanzvi Alpha-Ketoglutaric Acid poda mutengesi kwemakore akati wandei, isu tinopa zvigadzirwa nemutengo unokwikwidza, uye chigadzirwa chedu ndechemhando yepamusoro uye chinoedzwa kwakasimba, kwakazvimirira kuti tive nechokwadi chekuti chakachengeteka kushandiswa pasirese.

Dheuteronomio:

  1. Abrahams JP, Leslie AG, Lutter R, Walker JE. Maumbirwo e2.8 Kugadziriswa kweF1-ATPase kubva kumombe yemoyo mitochondria. Zvisikwa. 1994; 370: 621-628. doi: 10.1038 / 370621a0.
  2. Alpers DH. Glutamine: ko iyo data inotsigira iyo chikonzero che glutamine yekuwedzera mune vanhu? Gastroenterology. 2006; 130: S106-S116. doi: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Muscle uye plasma amino acids zvichitevera kukuvara. Ann Kuvhiya. 1980; 192: 78-85. doi: 10.1097 / 00000658-198007000-00014.